TY - JOUR
T1 - Application of the incremental identification method to the formate oxidation using formate dehydrogenase
AU - Michalik, Claas
AU - Schmidt, Thomas
AU - Zavrel, Michael
AU - Ansorge-Schumacher, Marion
AU - Spiess, Antje
AU - Marquardt, Wolfgang
N1 - Funding Information:
We gratefully acknowledge the financial support by the Deutsche Forschungsgemeinschaft (DFG) via the collaborative research center 540 (SFB 540). We would also like to thank the reviewers as well as André Bardow for their fruitful comments that helped increasing the quality of this manuscript.
PY - 2007/9
Y1 - 2007/9
N2 - In this paper we apply the incremental method for the identification of reaction kinetics [Brendel, M., Bonvin, D., Marquardt, W., 2006. Incremental identification of complex reaction kinetics in homogeneous systems. Chemical Engineering Science 61, 5404-5420] to the oxidation of formate by dehydrogenase. For the identification task little a priori knowledge is assumed and thus a high number of model candidates have to be considered. In order to identify the best model from a set of candidates the number of candidates is efficiently reduced in a first step using the incremental method. In a second step the best model and its parameters are determined based on the reduced candidate set in a statistically sound manner using the classical simultaneous method.
AB - In this paper we apply the incremental method for the identification of reaction kinetics [Brendel, M., Bonvin, D., Marquardt, W., 2006. Incremental identification of complex reaction kinetics in homogeneous systems. Chemical Engineering Science 61, 5404-5420] to the oxidation of formate by dehydrogenase. For the identification task little a priori knowledge is assumed and thus a high number of model candidates have to be considered. In order to identify the best model from a set of candidates the number of candidates is efficiently reduced in a first step using the incremental method. In a second step the best model and its parameters are determined based on the reduced candidate set in a statistically sound manner using the classical simultaneous method.
KW - Biocatalysis
KW - Biochemical engineering
KW - Enzyme
KW - Formate dehydrogenase
KW - Model identification
KW - Parameter estimation
KW - Reaction engineering
UR - http://www.scopus.com/inward/record.url?scp=34547954523&partnerID=8YFLogxK
U2 - 10.1016/j.ces.2006.12.072
DO - 10.1016/j.ces.2006.12.072
M3 - Article
AN - SCOPUS:34547954523
SN - 0009-2509
VL - 62
SP - 5592
EP - 5597
JO - Chemical Engineering Science
JF - Chemical Engineering Science
IS - 18-20
ER -