Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Christian G. Hartinger, Michael Groessl, Samuel M. Meier, Angela Casini, Paul J. Dyson

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of these coordination compounds and especially of next generation drug candidates have not been fully elucidated. Due to the fact that DNA is considered a crucial target for platinum chemotherapeutics, metallodrug–DNA binding studies dominated the field for a long time. However, more recently, alternative targets were considered, including enzymes and proteins that may play a role in the overall pharmacological and toxicological profile of metallodrugs. This review focuses on MS-based techniques for studying anticancer metallodrugs in vivo, in vitro and in situ to delineate their modes-of-action.

Original languageEnglish
Pages (from-to)6186-6199
Number of pages14
JournalChemical Society Reviews
Volume42
Issue number14
DOIs
StatePublished - 24 Jun 2013
Externally publishedYes

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