Application of Crabtree/Pfaltz-Type Iridium Complexes for the Catalyzed Asymmetric Hydrogenation of an Agrochemical Building Block

Jacob Schneekönig, Weiping Liu, Thomas Leischner, Kathrin Junge, Christoph Schotes, Christian Beier, Matthias Beller

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Herein we report improved chemo- A nd enantioselective hydrogenations of 1-(2,2,4-trimethylquinolin-1(2H)-yl)ethan-1-one (1) toward (R)-1-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one (2) using well-defined novel Crabtree-type iridium complexes.

Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalOrganic Process Research and Development
Volume24
Issue number3
DOIs
StatePublished - 20 Mar 2020
Externally publishedYes

Keywords

  • N-heterocycles
  • alkene reduction
  • asymmetric hydrogenation
  • catalyst design
  • iridium catalysis
  • unactivated olefins

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