Apolipoprotein e genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

Johannes Boehm, Stefan Eichhorn, Matthias Kornek, Katharina Hauner, Anatol Prinzing, Joachim Grammer, Harald Lahm, Stefan Wagenpfeil, Ruediger Lange

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objectives: Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short- and long-term outcome. We analyzed two common genetic polymorphisms that have previously been linked to renal failure and inflammation, and have been supposed to be associated with cardiac surgery associated-acute kidney injury (CSA-AKI). Methods: A total of 1415 consecutive patients who underwent elective cardiac surgery with CPB at our institution were prospectively enrolled. Patients were genotyped for Apolipoprotein E (ApoE E2,E3,E4) (rs429358 and rs7412) and TNF-α-308G>A (rs1800629). Results: Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between ApoE (E2,E3,E4) and TNF-α-308G>A genotypes and the RIFLE criteria could be detected. Several multiple linear regression analyses for postoperative creatinine increase revealed highly significant associations for aortic cross clamp time (p<0.001), CPB-time (p<0.001), norepinephrine (p<0.001), left ventricular function (p=0.004) and blood transfusion (p<0.001). No associations were found for ApoE (E2,E3,E4) and TNF-α-308G>A genotypes or baseline creatinine. When the sample size is 1415, the multiple linear regression test of R2=0 for seven covariates assuming normal distribution will have at least 99% power with significance level 0.05 to detect an R2 of 0.108 or 0.107 as observed in the data. Conclusions: ApoE (E2,E3,E4) polymorphism and the TNF-α-308G>A polymorphism are not associated with renal injury after CPB.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalRenal Failure
Volume36
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • Acute kidney injury
  • Apolipoprotein E (E2
  • Cardiac surgery
  • E3
  • E4)
  • Genetics
  • TNF-α-308G>A

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