Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change

C. Czech, H. Förstl, F. Hentschel, U. Mönning, C. Besthorn, C. Geiger-Kabisch, H. Sattel, C. Masters, K. Beyreuther

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P<0.01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts were verified in this preliminary study.

Original languageEnglish
Pages (from-to)291-292
Number of pages2
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume243
Issue number5
DOIs
StatePublished - Feb 1994
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apolipoprotein E-4
  • Cholesterol
  • Leuko-araiosis cerebral infarct

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