Apathy in patients with Alzheimer's disease is a cost-driving factor

Christopher Kruse; Franziska Maier; Annika Spottke; Jan Philipp Bach; Claudia Bartels; Katharina Buerger; Andreas Fellgiebel; Klaus Fliessbach; Lutz Frölich; Lucrezia Hausner; Martin Hellmich; Stefan Klöppel; Arne Klostermann; Johannes Kornhuber; Christoph Laske; Oliver Peters; Josef Priller; Tanja Richter-Schmidinger; Anja Schneider; Kija Shah-Hosseini; Stefan Teipel; Christine A.F. von Arnim; Jens Wiltfang; Hendrik van der Wurp; Richard Dodel; Frank Jessen

doi:10.1002/alz.12915

Apathy in patients with Alzheimer's disease is a cost-driving factor

Christopher Kruse, Franziska Maier, Annika Spottke, Jan Philipp Bach, Claudia Bartels, Katharina Buerger, Andreas Fellgiebel, Klaus Fliessbach, Lutz Frölich, Lucrezia Hausner, Martin Hellmich, Stefan Klöppel, Arne Klostermann, Johannes Kornhuber, Christoph Laske, Oliver Peters, Josef Priller, Tanja Richter-Schmidinger, Anja Schneider, Kija Shah-HosseiniStefan Teipel, Christine A.F. von Arnim, Jens Wiltfang, Hendrik van der Wurp, Richard Dodel, Frank Jessen

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Apathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. Methods: Included were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). Results: On average, total monthly costs were €3070, of which €2711 accounted for caregivers’ and €359 for patients’ costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. Discussion: Apathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

Original language	English
Pages (from-to)	2853-2864
Number of pages	12
Journal	Alzheimer's and Dementia
Volume	19
Issue number	7
DOIs	https://doi.org/10.1002/alz.12915
State	Published - Jul 2023
Externally published	Yes

Keywords

Alzheimer's disease
apathy
cost of illness
dementia
economics
resource use

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/alz.12915

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Kruse, C., Maier, F., Spottke, A., Bach, J. P., Bartels, C., Buerger, K., Fellgiebel, A., Fliessbach, K., Frölich, L., Hausner, L., Hellmich, M., Klöppel, S., Klostermann, A., Kornhuber, J., Laske, C., Peters, O., Priller, J., Richter-Schmidinger, T., Schneider, A., ... Jessen, F. (2023). Apathy in patients with Alzheimer's disease is a cost-driving factor. Alzheimer's and Dementia, 19(7), 2853-2864. https://doi.org/10.1002/alz.12915

@article{32a7928d4de144cbbd34e831face434f,

title = "Apathy in patients with Alzheimer's disease is a cost-driving factor",

abstract = "Background: Apathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. Methods: Included were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). Results: On average, total monthly costs were €3070, of which €2711 accounted for caregivers{\textquoteright} and €359 for patients{\textquoteright} costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. Discussion: Apathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.",

keywords = "Alzheimer's disease, apathy, cost of illness, dementia, economics, resource use",

author = "Christopher Kruse and Franziska Maier and Annika Spottke and Bach, {Jan Philipp} and Claudia Bartels and Katharina Buerger and Andreas Fellgiebel and Klaus Fliessbach and Lutz Fr{\"o}lich and Lucrezia Hausner and Martin Hellmich and Stefan Kl{\"o}ppel and Arne Klostermann and Johannes Kornhuber and Christoph Laske and Oliver Peters and Josef Priller and Tanja Richter-Schmidinger and Anja Schneider and Kija Shah-Hosseini and Stefan Teipel and {von Arnim}, {Christine A.F.} and Jens Wiltfang and {van der Wurp}, Hendrik and Richard Dodel and Frank Jessen",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2023",

month = jul,

doi = "10.1002/alz.12915",

language = "English",

volume = "19",

pages = "2853--2864",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

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}

Kruse, C, Maier, F, Spottke, A, Bach, JP, Bartels, C, Buerger, K, Fellgiebel, A, Fliessbach, K, Frölich, L, Hausner, L, Hellmich, M, Klöppel, S, Klostermann, A, Kornhuber, J, Laske, C, Peters, O, Priller, J, Richter-Schmidinger, T, Schneider, A, Shah-Hosseini, K, Teipel, S, von Arnim, CAF, Wiltfang, J, van der Wurp, H, Dodel, R & Jessen, F 2023, 'Apathy in patients with Alzheimer's disease is a cost-driving factor', Alzheimer's and Dementia, vol. 19, no. 7, pp. 2853-2864. https://doi.org/10.1002/alz.12915

TY - JOUR

T1 - Apathy in patients with Alzheimer's disease is a cost-driving factor

AU - Kruse, Christopher

AU - Maier, Franziska

AU - Spottke, Annika

AU - Bach, Jan Philipp

AU - Bartels, Claudia

AU - Buerger, Katharina

AU - Fellgiebel, Andreas

AU - Fliessbach, Klaus

AU - Frölich, Lutz

AU - Hausner, Lucrezia

AU - Hellmich, Martin

AU - Klöppel, Stefan

AU - Klostermann, Arne

AU - Kornhuber, Johannes

AU - Laske, Christoph

AU - Peters, Oliver

AU - Priller, Josef

AU - Richter-Schmidinger, Tanja

AU - Schneider, Anja

AU - Shah-Hosseini, Kija

AU - Teipel, Stefan

AU - von Arnim, Christine A.F.

AU - Wiltfang, Jens

AU - van der Wurp, Hendrik

AU - Dodel, Richard

AU - Jessen, Frank

PY - 2023/7

Y1 - 2023/7

N2 - Background: Apathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. Methods: Included were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). Results: On average, total monthly costs were €3070, of which €2711 accounted for caregivers’ and €359 for patients’ costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. Discussion: Apathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

AB - Background: Apathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers. Methods: Included were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1-month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO). Results: On average, total monthly costs were €3070, of which €2711 accounted for caregivers’ and €359 for patients’ costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs. Discussion: Apathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

KW - Alzheimer's disease

KW - apathy

KW - cost of illness

KW - dementia

KW - economics

KW - resource use

UR - http://www.scopus.com/inward/record.url?scp=85145419314&partnerID=8YFLogxK

U2 - 10.1002/alz.12915

DO - 10.1002/alz.12915

M3 - Article

C2 - 36588502

AN - SCOPUS:85145419314

SN - 1552-5260

VL - 19

SP - 2853

EP - 2864

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 7

ER -

Apathy in patients with Alzheimer's disease is a cost-driving factor

Abstract

Keywords

UN SDGs

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