Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

Xin Lan; Tian Mi; Shanta Alli; Cliff Guy; Mohamed Nadhir Djekidel; Xueyan Liu; Shannon Boi; Partha Chowdhury; Minghong He; Dietmar Zehn; Yongqiang Feng; Ben Youngblood

doi:10.1038/s41590-024-01843-8

Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

Xin Lan
, Tian Mi
, Shanta Alli
, Cliff Guy
, Mohamed Nadhir Djekidel
, Xueyan Liu
, Shannon Boi
, Partha Chowdhury
, Minghong He
, Dietmar Zehn
, Yongqiang Feng
, Ben Youngblood

Chair of Animal Physiology and Immunology

St. Jude Children's Research Hospital
University of Tennessee Health Science Center
University of New Orleans

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

Original language	English
Pages (from-to)	1046-1058
Number of pages	13
Journal	Nature Immunology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1038/s41590-024-01843-8
State	Published - Jun 2024

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10.1038/s41590-024-01843-8

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title = "Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement",

abstract = "Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.",

author = "Xin Lan and Tian Mi and Shanta Alli and Cliff Guy and Djekidel, \{Mohamed Nadhir\} and Xueyan Liu and Shannon Boi and Partha Chowdhury and Minghong He and Dietmar Zehn and Yongqiang Feng and Ben Youngblood",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2024..",

year = "2024",

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doi = "10.1038/s41590-024-01843-8",

language = "English",

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journal = "Nature Immunology",

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T1 - Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

AU - Lan, Xin

AU - Mi, Tian

AU - Alli, Shanta

AU - Guy, Cliff

AU - Djekidel, Mohamed Nadhir

AU - Liu, Xueyan

AU - Boi, Shannon

AU - Chowdhury, Partha

AU - He, Minghong

AU - Zehn, Dietmar

AU - Feng, Yongqiang

AU - Youngblood, Ben

PY - 2024/6

Y1 - 2024/6

N2 - Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

AB - Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

UR - https://www.scopus.com/pages/publications/85194706838

U2 - 10.1038/s41590-024-01843-8

DO - 10.1038/s41590-024-01843-8

M3 - Article

AN - SCOPUS:85194706838

SN - 1529-2908

VL - 25

SP - 1046

EP - 1058

JO - Nature Immunology

JF - Nature Immunology

IS - 6

ER -

Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

Abstract

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