Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

Xin Lan, Tian Mi, Shanta Alli, Cliff Guy, Mohamed Nadhir Djekidel, Xueyan Liu, Shannon Boi, Partha Chowdhury, Minghong He, Dietmar Zehn, Yongqiang Feng, Ben Youngblood

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

Original languageEnglish
Pages (from-to)1046-1058
Number of pages13
JournalNature Immunology
Volume25
Issue number6
DOIs
StatePublished - Jun 2024

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