Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

Xin Lan; Tian Mi; Shanta Alli; Cliff Guy; Mohamed Nadhir Djekidel; Xueyan Liu; Shannon Boi; Partha Chowdhury; Minghong He; Dietmar Zehn; Yongqiang Feng; Ben Youngblood

doi:10.1038/s41590-024-01843-8

Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

Xin Lan, Tian Mi, Shanta Alli, Cliff Guy, Mohamed Nadhir Djekidel, Xueyan Liu, Shannon Boi, Partha Chowdhury, Minghong He, Dietmar Zehn, Yongqiang Feng, Ben Youngblood

Chair of Animal Physiology and Immunology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

Original language	English
Pages (from-to)	1046-1058
Number of pages	13
Journal	Nature Immunology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1038/s41590-024-01843-8
State	Published - Jun 2024

Access to Document

10.1038/s41590-024-01843-8

Cite this

@article{d005b97211c54d71a101bf21bc6d21ed,

title = "Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement",

abstract = "Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.",

author = "Xin Lan and Tian Mi and Shanta Alli and Cliff Guy and Djekidel, {Mohamed Nadhir} and Xueyan Liu and Shannon Boi and Partha Chowdhury and Minghong He and Dietmar Zehn and Yongqiang Feng and Ben Youngblood",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2024..",

year = "2024",

month = jun,

doi = "10.1038/s41590-024-01843-8",

language = "English",

volume = "25",

pages = "1046--1058",

journal = "Nature Immunology",

issn = "1529-2908",

publisher = "Nature Research",

number = "6",

}

TY - JOUR

T1 - Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement

AU - Lan, Xin

AU - Mi, Tian

AU - Alli, Shanta

AU - Guy, Cliff

AU - Djekidel, Mohamed Nadhir

AU - Liu, Xueyan

AU - Boi, Shannon

AU - Chowdhury, Partha

AU - He, Minghong

AU - Zehn, Dietmar

AU - Feng, Yongqiang

AU - Youngblood, Ben

PY - 2024/6

Y1 - 2024/6

N2 - Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

AB - Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

UR - http://www.scopus.com/inward/record.url?scp=85194706838&partnerID=8YFLogxK

U2 - 10.1038/s41590-024-01843-8

DO - 10.1038/s41590-024-01843-8

M3 - Article

AN - SCOPUS:85194706838

SN - 1529-2908

VL - 25

SP - 1046

EP - 1058

JO - Nature Immunology

JF - Nature Immunology

IS - 6

ER -

Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

Abstract

Access to Document

Other files and links

Fingerprint

Cite this