Antiplasmodial effects of a few selected natural flavonoids and their modulation of artemisinin activity

Anna Rita Bilia; Anna Rosa Sannella; Franco Francesco Vincieri; Luigi Messori; Angela Casini; Chiara Gabbiani; Carlo Severini; Giancarlo Majori

doi:10.1177/1934578x0800301212

Antiplasmodial effects of a few selected natural flavonoids and their modulation of artemisinin activity

Anna Rita Bilia, Anna Rosa Sannella, Franco Francesco Vincieri, Luigi Messori, Angela Casini, Chiara Gabbiani, Carlo Severini, Giancarlo Majori

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The direct antiplasmodial effects of five structurally-related flavonoids, namely quercetin, rutin, eriodictyol, eriodictyolchalcone and catechin, were analyzed in vitro on P. falciparum. Notably, all these flavonoids, with the only exception of rutin, caused relevant inhibition of P. falciparum growth when given at 1 mM concentration. In addition, they were found to affect greatly the potent antiplasmodial activity of artemisinin, leading to significant additive and even synergistic effects. In particular, quercetin induced a pronounced synergistic effect. The observed synergisms might be conveniently exploited to design new and/or more effective combination therapies.

Original language	English
Pages (from-to)	1999-2002
Number of pages	4
Journal	Natural Product Communications
Volume	3
Issue number	12
DOIs	https://doi.org/10.1177/1934578x0800301212
State	Published - 2008
Externally published	Yes

Keywords

Additive and synergistic effects
Artemisinin
Eriodictyol
Eriodictyolchalcone and catechin
Flavonoids
Plasmodium falciparum
Quercetin
Rutin

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10.1177/1934578x0800301212

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title = "Antiplasmodial effects of a few selected natural flavonoids and their modulation of artemisinin activity",

abstract = "The direct antiplasmodial effects of five structurally-related flavonoids, namely quercetin, rutin, eriodictyol, eriodictyolchalcone and catechin, were analyzed in vitro on P. falciparum. Notably, all these flavonoids, with the only exception of rutin, caused relevant inhibition of P. falciparum growth when given at 1 mM concentration. In addition, they were found to affect greatly the potent antiplasmodial activity of artemisinin, leading to significant additive and even synergistic effects. In particular, quercetin induced a pronounced synergistic effect. The observed synergisms might be conveniently exploited to design new and/or more effective combination therapies.",

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T1 - Antiplasmodial effects of a few selected natural flavonoids and their modulation of artemisinin activity

AU - Bilia, Anna Rita

AU - Sannella, Anna Rosa

AU - Vincieri, Franco Francesco

AU - Messori, Luigi

AU - Casini, Angela

AU - Gabbiani, Chiara

AU - Severini, Carlo

AU - Majori, Giancarlo

PY - 2008

Y1 - 2008

N2 - The direct antiplasmodial effects of five structurally-related flavonoids, namely quercetin, rutin, eriodictyol, eriodictyolchalcone and catechin, were analyzed in vitro on P. falciparum. Notably, all these flavonoids, with the only exception of rutin, caused relevant inhibition of P. falciparum growth when given at 1 mM concentration. In addition, they were found to affect greatly the potent antiplasmodial activity of artemisinin, leading to significant additive and even synergistic effects. In particular, quercetin induced a pronounced synergistic effect. The observed synergisms might be conveniently exploited to design new and/or more effective combination therapies.

AB - The direct antiplasmodial effects of five structurally-related flavonoids, namely quercetin, rutin, eriodictyol, eriodictyolchalcone and catechin, were analyzed in vitro on P. falciparum. Notably, all these flavonoids, with the only exception of rutin, caused relevant inhibition of P. falciparum growth when given at 1 mM concentration. In addition, they were found to affect greatly the potent antiplasmodial activity of artemisinin, leading to significant additive and even synergistic effects. In particular, quercetin induced a pronounced synergistic effect. The observed synergisms might be conveniently exploited to design new and/or more effective combination therapies.

KW - Additive and synergistic effects

KW - Artemisinin

KW - Eriodictyol

KW - Eriodictyolchalcone and catechin

KW - Flavonoids

KW - Plasmodium falciparum

KW - Quercetin

KW - Rutin

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U2 - 10.1177/1934578x0800301212

DO - 10.1177/1934578x0800301212

M3 - Article

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VL - 3

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EP - 2002

JO - Natural Product Communications

JF - Natural Product Communications

IS - 12

ER -

Antiplasmodial effects of a few selected natural flavonoids and their modulation of artemisinin activity

Abstract

Keywords

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