Abstract
Both phenylbutazon and mofebutazon inhibit oxidative fragmentation of the methionine derivative, 2-keto-4-methylthio-butyric acid (KMB) by xanthine oxidase -or diaphorase mediated OH radical production. Differentiation of the two non-steroidal antiinflammatory drugs is possible by means of determining oxygen reduction by xanthine oxidase or diaphorase in the presence o f the naphthoquinone, juglone, where only mofebutazon shows an inhibitory effect.
| Original language | English |
|---|---|
| Pages (from-to) | 542-544 |
| Number of pages | 3 |
| Journal | Zeitschrift fur Naturforschung - Section C Journal of Biosciences |
| Volume | 48 |
| Issue number | 7-8 |
| DOIs | |
| State | Published - 1 Aug 1993 |
Keywords
- Mofebutazon
- Non Steroidal Antiinflammatory Drugs (NSAIDs)
- Oxygen Activation
- Phenylbutazon
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