Antimicrobial compounds from terminalia brownii against sweet potato pathogens

Sylvia A. Opiyo; Lawrence O.A. Manguro; Philip O. Owuor; Charles O. Ochieng; Elijah M. Ateka; Peter Lemmen

doi:10.2174/2210315511101020116

Antimicrobial compounds from terminalia brownii against sweet potato pathogens

Sylvia A. Opiyo, Lawrence O.A. Manguro, Philip O. Owuor, Charles O. Ochieng, Elijah M. Ateka, Peter Lemmen

Natural Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Phytochemical evaluation of Terminalia brownii extracts led to the isolation of five compounds namely β-sitosterol, stigmasterol, monogynol A, betulinic acid and arjungenin. Their structures were established by spectroscopic and physical methods as well as by comparison with literature data. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (p ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol ones. Streptomyces ipomoeae was more susceptible to ethyl acetate extract (inhibition zone, 18.6 mm) than streptocycline used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 50 and 200 μg/ml with the lowest MIC value of 50 μg/ml being observed with betulinic acid against Aspergillus niger and S. ipomoea.

Original language	English
Pages (from-to)	116-120
Number of pages	5
Journal	Natural Products Journal
Volume	1
Issue number	2
DOIs	https://doi.org/10.2174/2210315511101020116
State	Published - 2011

Keywords

Antibacterial
Antifungal
Combretaceae
Isolates
MIC
Sterols
Terminalia brownii
Triterpenes

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title = "Antimicrobial compounds from terminalia brownii against sweet potato pathogens",

abstract = "Phytochemical evaluation of Terminalia brownii extracts led to the isolation of five compounds namely β-sitosterol, stigmasterol, monogynol A, betulinic acid and arjungenin. Their structures were established by spectroscopic and physical methods as well as by comparison with literature data. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (p ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol ones. Streptomyces ipomoeae was more susceptible to ethyl acetate extract (inhibition zone, 18.6 mm) than streptocycline used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 50 and 200 μg/ml with the lowest MIC value of 50 μg/ml being observed with betulinic acid against Aspergillus niger and S. ipomoea.",

keywords = "Antibacterial, Antifungal, Combretaceae, Isolates, MIC, Sterols, Terminalia brownii, Triterpenes",

author = "Opiyo, {Sylvia A.} and Manguro, {Lawrence O.A.} and Owuor, {Philip O.} and Ochieng, {Charles O.} and Ateka, {Elijah M.} and Peter Lemmen",

year = "2011",

doi = "10.2174/2210315511101020116",

language = "English",

volume = "1",

pages = "116--120",

journal = "Natural Products Journal",

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T1 - Antimicrobial compounds from terminalia brownii against sweet potato pathogens

AU - Opiyo, Sylvia A.

AU - Manguro, Lawrence O.A.

AU - Owuor, Philip O.

AU - Ochieng, Charles O.

AU - Ateka, Elijah M.

AU - Lemmen, Peter

PY - 2011

Y1 - 2011

N2 - Phytochemical evaluation of Terminalia brownii extracts led to the isolation of five compounds namely β-sitosterol, stigmasterol, monogynol A, betulinic acid and arjungenin. Their structures were established by spectroscopic and physical methods as well as by comparison with literature data. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (p ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol ones. Streptomyces ipomoeae was more susceptible to ethyl acetate extract (inhibition zone, 18.6 mm) than streptocycline used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 50 and 200 μg/ml with the lowest MIC value of 50 μg/ml being observed with betulinic acid against Aspergillus niger and S. ipomoea.

AB - Phytochemical evaluation of Terminalia brownii extracts led to the isolation of five compounds namely β-sitosterol, stigmasterol, monogynol A, betulinic acid and arjungenin. Their structures were established by spectroscopic and physical methods as well as by comparison with literature data. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (p ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol ones. Streptomyces ipomoeae was more susceptible to ethyl acetate extract (inhibition zone, 18.6 mm) than streptocycline used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 50 and 200 μg/ml with the lowest MIC value of 50 μg/ml being observed with betulinic acid against Aspergillus niger and S. ipomoea.

KW - Antibacterial

KW - Antifungal

KW - Combretaceae

KW - Isolates

KW - MIC

KW - Sterols

KW - Terminalia brownii

KW - Triterpenes

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U2 - 10.2174/2210315511101020116

DO - 10.2174/2210315511101020116

M3 - Article

AN - SCOPUS:84976351531

SN - 2210-3155

VL - 1

SP - 116

EP - 120

JO - Natural Products Journal

JF - Natural Products Journal

IS - 2

ER -

Antimicrobial compounds from terminalia brownii against sweet potato pathogens

Abstract

Keywords

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