Antimalarial properties of green tea

Anna Rosa Sannella; Luigi Messori; Angela Casini; Franco Francesco Vincieri; Anna Rita Bilia; Giancarlo Majori; Carlo Severini

doi:10.1016/j.bbrc.2006.12.005

Antimalarial properties of green tea

Anna Rosa Sannella, Luigi Messori, Angela Casini, Franco Francesco Vincieri, Anna Rita Bilia, Giancarlo Majori, Carlo Severini

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	353
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2006.12.005
State	Published - 2 Feb 2007
Externally published	Yes

Keywords

Artemisinin
Catechins
Green tea
Malaria
Plasmodium falciparum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbrc.2006.12.005

Cite this

@article{b14156ba4dce4440b103ec52295ef945,

title = "Antimalarial properties of green tea",

abstract = "We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.",

keywords = "Artemisinin, Catechins, Green tea, Malaria, Plasmodium falciparum",

author = "Sannella, {Anna Rosa} and Luigi Messori and Angela Casini and {Francesco Vincieri}, Franco and Bilia, {Anna Rita} and Giancarlo Majori and Carlo Severini",

note = "Funding Information: The Ente Cassa di Risparmio di Firenze is gratefully acknowledged for generous financial support. We thank L. Gradoni and A. Savarino for help in data analysis. ",

year = "2007",

month = feb,

day = "2",

doi = "10.1016/j.bbrc.2006.12.005",

language = "English",

volume = "353",

pages = "177--181",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Antimalarial properties of green tea

AU - Sannella, Anna Rosa

AU - Messori, Luigi

AU - Casini, Angela

AU - Francesco Vincieri, Franco

AU - Bilia, Anna Rita

AU - Majori, Giancarlo

AU - Severini, Carlo

N1 - Funding Information: The Ente Cassa di Risparmio di Firenze is gratefully acknowledged for generous financial support. We thank L. Gradoni and A. Savarino for help in data analysis.

PY - 2007/2/2

Y1 - 2007/2/2

N2 - We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.

AB - We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.

KW - Artemisinin

KW - Catechins

KW - Green tea

KW - Malaria

KW - Plasmodium falciparum

UR - http://www.scopus.com/inward/record.url?scp=33845747244&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2006.12.005

DO - 10.1016/j.bbrc.2006.12.005

M3 - Article

C2 - 17174271

AN - SCOPUS:33845747244

SN - 0006-291X

VL - 353

SP - 177

EP - 181

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Antimalarial properties of green tea

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this