Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration

Hyoung Lyoo Chul; Holger Prokisch; Thomas Meitinger; Yeob Lee Seung; Hyoun Kim Do; Sik Lee Myung

doi:10.1002/mds.21799

Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration

Hyoung Lyoo Chul, Holger Prokisch, Thomas Meitinger, Yeob Lee Seung, Hyoun Kim Do, Sik Lee Myung

Medicine and Health

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11 Scopus citations

Abstract

A 43-year-old male patient suddenly developed freezing of gait (FOG) when making a first step, turning, or passing through a narrow path. Dystonic plantar flexion of his left foot always accompanied with FOG. He could walk without FOG when stepping on visual cues. Brain magnetic resonance imaging study showed typical "eye of the tiger" sign in the globus pallidus. He had heterozygous mutations in the exons 3 and 4 in the PANK2 gene. His FOG dramatically responded to the anticholinergic treatment. We report the first instance of a patient with genetically confirmed pantothenate kinase associated neurodegeneration showing typical FOG that responded to anticholinergic treatment.

Original language	English
Pages (from-to)	283-284
Number of pages	2
Journal	Movement Disorders
Volume	23
Issue number	2
DOIs	https://doi.org/10.1002/mds.21799
State	Published - 30 Jan 2008

Keywords

Anticholinergic
Gait freezing
Pantothenate kinase-associated neurodegeneration

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abstract = "A 43-year-old male patient suddenly developed freezing of gait (FOG) when making a first step, turning, or passing through a narrow path. Dystonic plantar flexion of his left foot always accompanied with FOG. He could walk without FOG when stepping on visual cues. Brain magnetic resonance imaging study showed typical {"}eye of the tiger{"} sign in the globus pallidus. He had heterozygous mutations in the exons 3 and 4 in the PANK2 gene. His FOG dramatically responded to the anticholinergic treatment. We report the first instance of a patient with genetically confirmed pantothenate kinase associated neurodegeneration showing typical FOG that responded to anticholinergic treatment.",

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AU - Do, Hyoun Kim

AU - Myung, Sik Lee

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Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration

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