Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand

Michaël Gras, Bruno Therrien, Georg Süss-Fink, Angela Casini, Fabio Edafe, Paul J. Dyson

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

The dinuclear dichloro complexes [(η6-arene)2Ru2(μ-Cl)2Cl2] and [(η5-C5Me5)2M2(μ-Cl)2Cl2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η6-arene)Ru(pyTz)Cl]+ (arene = C6H6 1, p-iPrC6H4Me 2 or C6Me6 3) and [(η5-C5Me5)M(pyTz)Cl]+ (M = Rh 4 or Ir 5), isolated as the chloride salts. The reaction of 2 and 3 with SnCl2 leads to the dinuclear heterometallic trichlorostannyl derivatives [(η6-p-iPrC6H4Me)Ru(pyTz)(SnCl3)]+ (6) and [(η6-C6Me6)Ru(pyTz)(SnCl3)]+ (7), respectively, also isolated as the chloride salts. The molecular structures of 4, 5 and 7 have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The in vitro anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated.

Original languageEnglish
Pages (from-to)1119-1125
Number of pages7
JournalJournal of Organometallic Chemistry
Volume695
Issue number8
DOIs
StatePublished - 15 Apr 2010
Externally publishedYes

Keywords

  • Anticancer agents
  • Arene ligands
  • Bioorganometallic
  • Iridium
  • Rhodium
  • Ruthenium

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