TY - JOUR
T1 - Antibiotic Coating of the Artificial Urinary Sphincter (AMS 800)
T2 - Is it Worthwhile?
AU - Debates On Male Incontinence (DOMINO)-Project
AU - Hüsch, Tanja
AU - Kretschmer, Alexander
AU - Thomsen, Frauke
AU - Kronlachner, Dominik
AU - Kurosch, Martin
AU - Obaje, Alice
AU - Anding, Ralf
AU - Pottek, Tobias
AU - Rose, Achim
AU - Olianas, Roberto
AU - Friedl, Alexander
AU - Hübner, Wilhelm
AU - Homberg, Roland
AU - Pfitzenmaier, Jesco
AU - Grein, Ulrich
AU - Queissert, Fabian
AU - Naumann, Carsten M.
AU - Schweiger, Josef
AU - Wotzka, Carola
AU - Nyarangi-Dix, Joanne
AU - Hofmann, Torben
AU - Ulm, Kurt
AU - Bauer, Ricarda M.
AU - Haferkamp, Axel
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/5
Y1 - 2017/5
N2 - Objective To investigate the impact of the antibiotic coating InhibiZone on the infection and explantation rates of the AMS 800 in comparison to the AMS 800 without InhibiZone. Materials and Methods We retrospectively identified 305 patients with an AMS 800 in a multicenter cohort study. Patients were subsequently divided into InhibiZone and without InhibiZone-coated groups. Infection and explantation rates were analyzed by univariate and consecutively by multivariate logistic regression adjusted to variable risk factors. The infection-free interval was estimated by Kaplan-Meier plot and compared by the log-rank test. A P value below.05 was considered statistically significant. Results We identified 47 patients with InhibiZone and 258 without InhibiZone coating. In univariate analysis, we could not identify a significant difference in infection (P = .932) or explantation (P = .715) rates between the groups. In multivariate analysis, impaired wound healing (P = .008) and urethral erosion (P < .001) were independent predictors for infection. The InhibiZone coating neither demonstrated significant influence on the infection rate (P = .534) nor on the explantation rate (P = .214). There was no significant difference in estimated infection-free survival between the groups (P = .265). Conclusion The antibiotic coating of the AMS 800 had no significant impact on infection or explantation rates in our cohort.
AB - Objective To investigate the impact of the antibiotic coating InhibiZone on the infection and explantation rates of the AMS 800 in comparison to the AMS 800 without InhibiZone. Materials and Methods We retrospectively identified 305 patients with an AMS 800 in a multicenter cohort study. Patients were subsequently divided into InhibiZone and without InhibiZone-coated groups. Infection and explantation rates were analyzed by univariate and consecutively by multivariate logistic regression adjusted to variable risk factors. The infection-free interval was estimated by Kaplan-Meier plot and compared by the log-rank test. A P value below.05 was considered statistically significant. Results We identified 47 patients with InhibiZone and 258 without InhibiZone coating. In univariate analysis, we could not identify a significant difference in infection (P = .932) or explantation (P = .715) rates between the groups. In multivariate analysis, impaired wound healing (P = .008) and urethral erosion (P < .001) were independent predictors for infection. The InhibiZone coating neither demonstrated significant influence on the infection rate (P = .534) nor on the explantation rate (P = .214). There was no significant difference in estimated infection-free survival between the groups (P = .265). Conclusion The antibiotic coating of the AMS 800 had no significant impact on infection or explantation rates in our cohort.
UR - https://www.scopus.com/pages/publications/85011357044
U2 - 10.1016/j.urology.2016.12.056
DO - 10.1016/j.urology.2016.12.056
M3 - Article
C2 - 28093308
AN - SCOPUS:85011357044
SN - 0090-4295
VL - 103
SP - 179
EP - 184
JO - Urology
JF - Urology
ER -