Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia

Friedhelm R. Schuster; Roland Meisel; Monika Führer; Susanne Reuther; Julia Hauer; Johanna Tischer; Tobias Feuchtinger; Hans Jürgen Laws; Hans Jochem Kolb; Arndt Borkhardt

doi:10.1111/bjh.12455

Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia

Friedhelm R. Schuster, Roland Meisel, Monika Führer, Susanne Reuther, Julia Hauer, Johanna Tischer, Tobias Feuchtinger, Hans Jürgen Laws, Hans Jochem Kolb, Arndt Borkhardt

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6 Scopus citations

Abstract

The treatment outcome of children with refractory acute leukaemia or relapse post-stem cell transplantation is dismal. We report 10 children (non-remission n = 7) who underwent a new haploidentical transplant approach utilizing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells. Nine patients had successful engraftment and no evidence of leukaemia. Acute and chronic graft-versus-host-disease was observed in five and three patients, respectively; two patients died of treatment-related toxicity. Seven patients relapsed after 7 (range 3-34) months, however two patients are alive at 6·5 and 7·0 years. This approach provides anti-leukaemic activity even in heavily pre-treated children but long-term disease control requires further intervention.

Original language	English
Pages (from-to)	802-807
Number of pages	6
Journal	British Journal of Haematology
Volume	162
Issue number	6
DOIs	https://doi.org/10.1111/bjh.12455
State	Published - Sep 2013
Externally published	Yes

Keywords

Acute refractory leukaemia
CD6-depletion
Graft-versus-leukaemia-effect
Haploidentical transplantation

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Schuster, F. R., Meisel, R., Führer, M., Reuther, S., Hauer, J., Tischer, J., Feuchtinger, T., Laws, H. J., Kolb, H. J., & Borkhardt, A. (2013). Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia. British Journal of Haematology, 162(6), 802-807. https://doi.org/10.1111/bjh.12455

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title = "Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia",

abstract = "The treatment outcome of children with refractory acute leukaemia or relapse post-stem cell transplantation is dismal. We report 10 children (non-remission n = 7) who underwent a new haploidentical transplant approach utilizing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells. Nine patients had successful engraftment and no evidence of leukaemia. Acute and chronic graft-versus-host-disease was observed in five and three patients, respectively; two patients died of treatment-related toxicity. Seven patients relapsed after 7 (range 3-34) months, however two patients are alive at 6·5 and 7·0 years. This approach provides anti-leukaemic activity even in heavily pre-treated children but long-term disease control requires further intervention.",

keywords = "Acute refractory leukaemia, CD6-depletion, Graft-versus-leukaemia-effect, Haploidentical transplantation",

author = "Schuster, {Friedhelm R.} and Roland Meisel and Monika F{\"u}hrer and Susanne Reuther and Julia Hauer and Johanna Tischer and Tobias Feuchtinger and Laws, {Hans J{\"u}rgen} and Kolb, {Hans Jochem} and Arndt Borkhardt",

year = "2013",

month = sep,

doi = "10.1111/bjh.12455",

language = "English",

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Schuster, FR, Meisel, R, Führer, M, Reuther, S, Hauer, J, Tischer, J, Feuchtinger, T, Laws, HJ, Kolb, HJ & Borkhardt, A 2013, 'Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia', British Journal of Haematology, vol. 162, no. 6, pp. 802-807. https://doi.org/10.1111/bjh.12455

Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia. / Schuster, Friedhelm R.; Meisel, Roland; Führer, Monika et al.
In: British Journal of Haematology, Vol. 162, No. 6, 09.2013, p. 802-807.

Research output: Contribution to journal › Article › peer-review

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AU - Meisel, Roland

AU - Führer, Monika

AU - Reuther, Susanne

AU - Hauer, Julia

AU - Tischer, Johanna

AU - Feuchtinger, Tobias

AU - Laws, Hans Jürgen

AU - Kolb, Hans Jochem

AU - Borkhardt, Arndt

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AB - The treatment outcome of children with refractory acute leukaemia or relapse post-stem cell transplantation is dismal. We report 10 children (non-remission n = 7) who underwent a new haploidentical transplant approach utilizing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells. Nine patients had successful engraftment and no evidence of leukaemia. Acute and chronic graft-versus-host-disease was observed in five and three patients, respectively; two patients died of treatment-related toxicity. Seven patients relapsed after 7 (range 3-34) months, however two patients are alive at 6·5 and 7·0 years. This approach provides anti-leukaemic activity even in heavily pre-treated children but long-term disease control requires further intervention.

KW - Acute refractory leukaemia

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Anti-leukaemic activity of a novel haploidentical-transplantation approach employing unmanipulated bone marrow followed by CD6-depleted peripheral blood stem cells in children with refractory/relapsed acute leukaemia

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Keywords

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