Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo

W. Dorsch; H. Wagner; Th Bayer; B. Fessler; G. Hein; J. Ring; P. Scheftner; W. Sieber; Th Strasser; E. Weiß

doi:10.1016/0006-2952(88)90663-6

Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo

W. Dorsch
, H. Wagner
, Th Bayer
, B. Fessler
, G. Hein
, J. Ring
, P. Scheftner
, W. Sieber
, Th Strasser
, E. Weiß

University of Munich

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B₄ and C₄ biosynthesis of human polymorphonuclear leucocytes, thromboxane B₂ biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: {A figure is presented}.

Original language	English
Pages (from-to)	4479-4486
Number of pages	8
Journal	Biochemical Pharmacology
Volume	37
Issue number	23
DOIs	https://doi.org/10.1016/0006-2952(88)90663-6
State	Published - 1 Dec 1988
Externally published	Yes

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Dorsch, W., Wagner, H., Bayer, T., Fessler, B., Hein, G., Ring, J., Scheftner, P., Sieber, W., Strasser, T., & Weiß, E. (1988). Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo. Biochemical Pharmacology, 37(23), 4479-4486. https://doi.org/10.1016/0006-2952(88)90663-6

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title = "Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo",

abstract = "Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: \{A figure is presented\}.",

author = "W. Dorsch and H. Wagner and Th Bayer and B. Fessler and G. Hein and J. Ring and P. Scheftner and W. Sieber and Th Strasser and E. Wei{\ss}",

year = "1988",

month = dec,

day = "1",

doi = "10.1016/0006-2952(88)90663-6",

language = "English",

volume = "37",

pages = "4479--4486",

journal = "Biochemical Pharmacology",

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Dorsch, W, Wagner, H, Bayer, T, Fessler, B, Hein, G, Ring, J, Scheftner, P, Sieber, W, Strasser, T & Weiß, E 1988, 'Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo', Biochemical Pharmacology, vol. 37, no. 23, pp. 4479-4486. https://doi.org/10.1016/0006-2952(88)90663-6

Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo. / Dorsch, W.; Wagner, H.; Bayer, Th et al.
In: Biochemical Pharmacology, Vol. 37, No. 23, 01.12.1988, p. 4479-4486.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo

AU - Dorsch, W.

AU - Wagner, H.

AU - Bayer, Th

AU - Fessler, B.

AU - Hein, G.

AU - Ring, J.

AU - Scheftner, P.

AU - Sieber, W.

AU - Strasser, Th

AU - Weiß, E.

PY - 1988/12/1

Y1 - 1988/12/1

N2 - Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: {A figure is presented}.

AB - Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: {A figure is presented}.

UR - https://www.scopus.com/pages/publications/0024271305

U2 - 10.1016/0006-2952(88)90663-6

DO - 10.1016/0006-2952(88)90663-6

M3 - Article

C2 - 2462422

AN - SCOPUS:0024271305

SN - 0006-2952

VL - 37

SP - 4479

EP - 4486

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 23

ER -

Dorsch W, Wagner H, Bayer T, Fessler B, Hein G, Ring J et al. Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo. Biochemical Pharmacology. 1988 Dec 1;37(23):4479-4486. doi: 10.1016/0006-2952(88)90663-6

Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract paf and allergen-induced bronchial obstruction in vivo

Abstract

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