Anomalous diffusion probes microstructure dynamics of entangled F-actin networks

I. Y. Wong; M. L. Gardel; D. R. Reichman; Eric R. Weeks; M. T. Valentine; A. R. Bausch; D. A. Weitz

doi:10.1103/PhysRevLett.92.178101

Anomalous diffusion probes microstructure dynamics of entangled F-actin networks

I. Y. Wong
, M. L. Gardel
, D. R. Reichman
, Eric R. Weeks
, M. T. Valentine
, A. R. Bausch
, D. A. Weitz

Chair of Cellular Biophysics

The Broad Institute of MIT and Harvard
Harvard University
Emory University

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

The thermal motion of colloidal tracer particles in entangled actin filament (F-actin) networks, where the particle radius is comparable to the mesh size of the F-actin network, was analyzed. The ensemble-averaged mean-squared displacement of the particles was proportional to τ^γ in this regime. The anomalous subdiffusion was determined by directly imaging hundreds of particles over 20 min. It was shown that this anomalous subdiffusion is due to the dynamics of infrequent and large jumps particles make between distinct pores in the network.

Original language	English
Article number	178101
Pages (from-to)	178101-1-178101-4
Journal	Physical Review Letters
Volume	92
Issue number	17
DOIs	https://doi.org/10.1103/PhysRevLett.92.178101
State	Published - 30 Apr 2004

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10.1103/PhysRevLett.92.178101

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title = "Anomalous diffusion probes microstructure dynamics of entangled F-actin networks",

abstract = "The thermal motion of colloidal tracer particles in entangled actin filament (F-actin) networks, where the particle radius is comparable to the mesh size of the F-actin network, was analyzed. The ensemble-averaged mean-squared displacement of the particles was proportional to τγ in this regime. The anomalous subdiffusion was determined by directly imaging hundreds of particles over 20 min. It was shown that this anomalous subdiffusion is due to the dynamics of infrequent and large jumps particles make between distinct pores in the network.",

author = "Wong, \{I. Y.\} and Gardel, \{M. L.\} and Reichman, \{D. R.\} and Weeks, \{Eric R.\} and Valentine, \{M. T.\} and Bausch, \{A. R.\} and Weitz, \{D. A.\}",

note = "Funding Information: We thank P. Benetatos for careful reading of the ?>manuscript. This work was funded by the NSF ?>(DMR-0243715) and the Harvard MRSEC (DMR-0213805). Other support was through the Harvard College Research Program (I. Y. W.), Emmy Noether Pro?>gram of the DFG (A. B.), and Lucent GRPW (M. L. G.). D. R. R. thanks the Alfred P. Sloan Foundation for financial support.",

year = "2004",

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doi = "10.1103/PhysRevLett.92.178101",

language = "English",

volume = "92",

pages = "178101--1--178101--4",

journal = "Physical Review Letters",

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AU - Wong, I. Y.

AU - Gardel, M. L.

AU - Reichman, D. R.

AU - Weeks, Eric R.

AU - Valentine, M. T.

AU - Bausch, A. R.

AU - Weitz, D. A.

N1 - Funding Information: We thank P. Benetatos for careful reading of the ?>manuscript. This work was funded by the NSF ?>(DMR-0243715) and the Harvard MRSEC (DMR-0213805). Other support was through the Harvard College Research Program (I. Y. W.), Emmy Noether Pro?>gram of the DFG (A. B.), and Lucent GRPW (M. L. G.). D. R. R. thanks the Alfred P. Sloan Foundation for financial support.

PY - 2004/4/30

Y1 - 2004/4/30

N2 - The thermal motion of colloidal tracer particles in entangled actin filament (F-actin) networks, where the particle radius is comparable to the mesh size of the F-actin network, was analyzed. The ensemble-averaged mean-squared displacement of the particles was proportional to τγ in this regime. The anomalous subdiffusion was determined by directly imaging hundreds of particles over 20 min. It was shown that this anomalous subdiffusion is due to the dynamics of infrequent and large jumps particles make between distinct pores in the network.

AB - The thermal motion of colloidal tracer particles in entangled actin filament (F-actin) networks, where the particle radius is comparable to the mesh size of the F-actin network, was analyzed. The ensemble-averaged mean-squared displacement of the particles was proportional to τγ in this regime. The anomalous subdiffusion was determined by directly imaging hundreds of particles over 20 min. It was shown that this anomalous subdiffusion is due to the dynamics of infrequent and large jumps particles make between distinct pores in the network.

UR - https://www.scopus.com/pages/publications/85048192416

U2 - 10.1103/PhysRevLett.92.178101

DO - 10.1103/PhysRevLett.92.178101

M3 - Article

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VL - 92

SP - 178101-1-178101-4

JO - Physical Review Letters

JF - Physical Review Letters

IS - 17

M1 - 178101

ER -

Anomalous diffusion probes microstructure dynamics of entangled F-actin networks

Abstract

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