Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study

Massimo A. Padalino, Nicola Franchetti, George E. Sarris, Mark Hazekamp, Thierry Carrel, Alessandro Frigiola, Jurgen Horer, Regine Roussin, Julie Cleuziou, Bart Meyns, Jose Fragata, Helena Telles, Anastasios C. Polimenakos, Katrien Francois, Altin Veshti, Jukka Salminen, Alvaro Gonzalez Rocafort, Matej Nosal, Luca Vedovelli, Eleftherios ProtopapasRoberto Tumbarello, Assunta Merola, Cinzia Pegoraro, Raffaella Motta, Giovanna Boccuzzo, Vladimir Sojak, Mauro Lo Rito, Federica Caldaroni, Domenico Corrado, Cristina Basso, Giovanni Stellin

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: Anomalous aortic origin of coronary arteries (AAOCA) is a rare abnormality, whose optimal management is still undefined. We describe early outcomes in patients treated with different management strategies. Methods: This is a retrospective clinical multicenter study including patients with AAOCA, undergoing or not surgical treatment. Patients with isolated high coronary take off and associated major congenital heart disease were excluded. Preoperative, intraoperative, anatomical and postoperative data were retrieved from a common database. Results: Among 217 patients, 156 underwent Surgical repair (median age 39 years, IQR: 15–53), while 61 were Medical (median age 15 years, IQR: 8–52), in whom AAOCA was incidentally diagnosed during screening or clinical evaluations. Surgical patients were more often symptomatic when compared to medical ones (87.2% vs 44.3%, p < 0.001). Coronary unroofing was the most frequent procedure (56.4%). Operative mortality was 1.3% (2 patients with preoperative severe heart failure). At a median follow up of 18 months (range 0.1–23 years), 89.9% of survivors are in NYHA ≤ II, while only 3 elderly surgical patients died late. Return to sport activity was significantly higher in Surgical patients (48.1% vs 18.2%, p < 0.001). Conclusions: Surgery for AAOCA is safe and with low morbidity. When compared to Medical patients, who remain on exercise restriction and medical therapy, surgical patients have a benefit in terms of symptoms and return to normal life. Since the long term-risk of sudden cardiac death is still unknown, we currently recommend accurate long term surveillance in all patients with AAOCA.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalInternational Journal of Cardiology
StatePublished - 15 Sep 2019
Externally publishedYes


  • Anomalous coronary arteries
  • Clinical management
  • Congenital
  • Outcomes
  • Surgery


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