Animal models of obesity and diabetes mellitus

Maximilian Kleinert; Christoffer Clemmensen; Susanna M. Hofmann; Mary C. Moore; Simone Renner; Stephen C. Woods; Peter Huypens; Johannes Beckers; Martin Hrabe De Angelis; Annette Schürmann; Mostafa Bakhti; Martin Klingenspor; Mark Heiman; Alan D. Cherrington; Michael Ristow; Heiko Lickert; Eckhard Wolf; Peter J. Havel; Timo D. Müller; Matthias H. Tschöp

doi:10.1038/nrendo.2017.161

Animal models of obesity and diabetes mellitus

Maximilian Kleinert, Christoffer Clemmensen, Susanna M. Hofmann, Mary C. Moore, Simone Renner, Stephen C. Woods, Peter Huypens, Johannes Beckers, Martin Hrabe De Angelis, Annette Schürmann, Mostafa Bakhti, Martin Klingenspor, Mark Heiman, Alan D. Cherrington, Michael Ristow, Heiko Lickert, Eckhard Wolf, Peter J. Havel, Timo D. Müller, Matthias H. Tschöp

Research output: Contribution to journal › Review article › peer-review

585 Scopus citations

Abstract

More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.

Original language	English
Pages (from-to)	140-162
Number of pages	23
Journal	Nature Reviews Endocrinology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1038/nrendo.2017.161
State	Published - 1 Mar 2018

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10.1038/nrendo.2017.161

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Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., De Angelis, M. H., Schürmann, A., Bakhti, M., Klingenspor, M., Heiman, M., Cherrington, A. D., Ristow, M., Lickert, H., Wolf, E., Havel, P. J., Müller, T. D., & Tschöp, M. H. (2018). Animal models of obesity and diabetes mellitus. Nature Reviews Endocrinology, 14(3), 140-162. https://doi.org/10.1038/nrendo.2017.161

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title = "Animal models of obesity and diabetes mellitus",

abstract = "More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.",

author = "Maximilian Kleinert and Christoffer Clemmensen and Hofmann, {Susanna M.} and Moore, {Mary C.} and Simone Renner and Woods, {Stephen C.} and Peter Huypens and Johannes Beckers and {De Angelis}, {Martin Hrabe} and Annette Sch{\"u}rmann and Mostafa Bakhti and Martin Klingenspor and Mark Heiman and Cherrington, {Alan D.} and Michael Ristow and Heiko Lickert and Eckhard Wolf and Havel, {Peter J.} and M{\"u}ller, {Timo D.} and Tsch{\"o}p, {Matthias H.}",

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Kleinert, M, Clemmensen, C, Hofmann, SM, Moore, MC, Renner, S, Woods, SC, Huypens, P, Beckers, J, De Angelis, MH, Schürmann, A, Bakhti, M, Klingenspor, M, Heiman, M, Cherrington, AD, Ristow, M, Lickert, H, Wolf, E, Havel, PJ, Müller, TD & Tschöp, MH 2018, 'Animal models of obesity and diabetes mellitus', Nature Reviews Endocrinology, vol. 14, no. 3, pp. 140-162. https://doi.org/10.1038/nrendo.2017.161

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AU - Huypens, Peter

AU - Beckers, Johannes

AU - De Angelis, Martin Hrabe

AU - Schürmann, Annette

AU - Bakhti, Mostafa

AU - Klingenspor, Martin

AU - Heiman, Mark

AU - Cherrington, Alan D.

AU - Ristow, Michael

AU - Lickert, Heiko

AU - Wolf, Eckhard

AU - Havel, Peter J.

AU - Müller, Timo D.

AU - Tschöp, Matthias H.

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Animal models of obesity and diabetes mellitus

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