Anilines made easily: From aldehydes to tri-, tetra-, and pentasubstituted anilines in two steps

Helfried Neumann, Axel Jacobi Von Wangelin, Stefan Klaus, Dirk Strübing, Dirk Gördes, Matthias Beller

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Easy as one, two, three. Highly substituted anilines are accessible with unprecedented efficiency from the three-component-coupling reaction of O-benzyl carbamate, aldehydes, and dienophiles followed by a new domino aromatization/deprotection reaction involving transfer hydrogenation (see scheme). EWG: electron-withdrawing group.

Original languageEnglish
Pages (from-to)4503-4507
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume42
Issue number37
DOIs
StatePublished - 29 Sep 2003
Externally publishedYes

Keywords

  • Anilines
  • Multicomponent reactions
  • Palladium
  • Transfer hydrogenation

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