Anesthesia and postoperative cognitive dysfunction (POCD)

Bettina Jungwirth; Walter Zieglgänsberger; Eberhard Kochs; Gerhard Rammes

doi:10.2174/138955709791012229

Anesthesia and postoperative cognitive dysfunction (POCD)

Bettina Jungwirth
, Walter Zieglgänsberger
, Eberhard Kochs
, Gerhard Rammes

Department of Anesthesiology and Intensive Care

Technical University of Munich
Max Planck Institute of Psychiatry

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

Original language	English
Pages (from-to)	1568-1579
Number of pages	12
Journal	Mini-Reviews in Medicinal Chemistry
Volume	9
Issue number	14
DOIs	https://doi.org/10.2174/138955709791012229
State	Published - Dec 2009

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title = "Anesthesia and postoperative cognitive dysfunction (POCD)",

abstract = "POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.",

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AU - Jungwirth, Bettina

AU - Zieglgänsberger, Walter

AU - Kochs, Eberhard

AU - Rammes, Gerhard

PY - 2009/12

Y1 - 2009/12

N2 - POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

AB - POCD describes a decline in cognitive function after surgery with a predominance in the elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it remains unclear whether its occurrence is a result of the effects of surgery or general anesthesia. This review provides a synopsis of the available clinical and preclinical data and summarizes recent research relevant to the occurrence of POCD and possible pharmacologic algorithms for its prevention and treatment.

UR - https://www.scopus.com/pages/publications/77949902773

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DO - 10.2174/138955709791012229

M3 - Review article

AN - SCOPUS:77949902773

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JO - Mini-Reviews in Medicinal Chemistry

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Anesthesia and postoperative cognitive dysfunction (POCD)

Abstract

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