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Anatomic versus physiologic assessment of coronary artery disease: Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making

  • K. Lance Gould
  • , Nils P. Johnson
  • , Timothy M. Bateman
  • , Rob S. Beanlands
  • , Frank M. Bengel
  • , Robert Bober
  • , Paolo G. Camici
  • , Manuel D. Cerqueira
  • , Benjamin J.W. Chow
  • , Marcelo F. Di Carli
  • , Sharmila Dorbala
  • , Henry Gewirtz
  • , Robert J. Gropler
  • , Philipp A. Kaufmann
  • , Paul Knaapen
  • , Juhani Knuuti
  • , Michael E. Merhige
  • , K. Peter Rentrop
  • , Terrence D. Ruddy
  • , Heinrich R. Schelbert
  • Thomas H. Schindler, Markus Schwaiger, Stefano Sdringola, John Vitarello, Kim A. Williams, Donald Gordon, Vasken Dilsizian, Jagat Narula
  • McGovern Medical School
  • University of Missouri-Kansas City
  • University of Ottawa Heart Institute
  • Medizinische Hochschule Hannover
  • Alton Ochsner Medical Foundation
  • University Vita-Salute San Raffaele
  • Cleveland Clinic Foundation
  • Brigham and Women's Hospital
  • Massachusetts General Hospital
  • Washington University School of Medicine in St. Louis, Mallinckrodt Institute of Radiology
  • University Hospital Zurich
  • Amsterdam University Medical Centers
  • Turku University Hospital
  • Heart Center of Niagara
  • Gramercy Cardiac Diagnostic Services
  • David Geffen School of Medicine at UCLA
  • Geneva University Hospitals
  • Cardiovascular Specialists of Frederick
  • Wayne State University School of Medicine
  • Cardiovascular Assoc. of the Southeast
  • University of Maryland School of Medicine
  • Mount Sinai School of Medicine

Research output: Contribution to journalReview articlepeer-review

521 Scopus citations

Abstract

Angiographic severity of coronary artery stenosis has historically been the primary guide to revascularization or medical management of coronary artery disease. However, physiologic severity defined by coronary pressure and/or flow has resurged into clinical prominence as a potential, fundamental change from anatomically to physiologically guided management. This review addresses clinical coronary physiology - pressure and flow - as clinical tools for treating patients. We clarify the basic concepts that hold true for whatever technology measures coronary physiology directly and reliably, here focusing on positron emission tomography and its interplay with intracoronary measurements.

Original languageEnglish
Pages (from-to)1639-1653
Number of pages15
JournalJournal of the American College of Cardiology
Volume62
Issue number18
DOIs
StatePublished - 29 Oct 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • PET perfusion imaging
  • coronary flow
  • coronary physiology
  • ischemia
  • revascularization

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