Anaphylaxis: Opportunities of stratified medicine for diagnosis and risk assessment

F. Wölbing, T. Biedermann

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

The risk to develop anaphylaxis depends on the sensitization pattern, the proportion of the involved immunoglobulin classes, the avidity and affinity of immunoglobulins to bind an allergen, characteristics of the allergen, the route of allergen application, and, last but not least, the presence of cofactors of anaphylaxis. To be able to calculate the risk to develop anaphylaxis and to anticipate the severity of the reactions under certain conditions, it is necessary to understand how all these factors interact with each other. Important progress for risk assessment in anaphylaxis is based on component-resolved stratified diagnostics, which allow to (i) determine a patient′s sensitization pattern on a molecular basis, (ii) correlate clinical responses to defined sensitization patterns, and (iii) better identify cross-reactive allergens. Together with the increasing knowledge regarding the role and mode of action of cofactors of anaphylaxis, these data pave the way to unscramble the complex interactions determining the clinical relevance of sensitizations, the risk of anaphylaxis, and the severity of reactions. As a consequence, this understanding allows to better determine the individual risk in response to an identified allergen and results in more specific advices and education for our patients to prevent further life-threatening anaphylactic reactions.

Original languageEnglish
Pages (from-to)1499-1508
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume68
Issue number12
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • anaphylaxis
  • augmentation factor
  • cofactor
  • component-resolved diagnostics
  • personalized medicine

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