Analysis of calcium channels by conditional mutagenesis

S. Moosmang, T. Kleppisch, J. Wegener, A. Welling, F. Hofmann

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

13 Scopus citations

Abstract

Ca2+ influx through various ion channels is an important determinant of the cytosolic Ca2+ concentration, which plays a pivotal role in countless cellular processes. The cardiac L-type Ca2+ channel, Cav1.2, represents a major pathway for Ca2+ entry and is in many cells expressed together with other high- and low-voltage-activated Ca2+ channels. This article will focus on the use of conditional transgenic mouse models to clarify the roles of Ca 2+ channels in several biological systems. The phenotypes of conditional Ca2+ channel transgenic mice have provided novel, and often unexpected, insights into the in vivo function of L-type and T-type Ca2+ channels as mediators of signaling between cell membrane and intracellular processes in blood pressure regulation, smooth muscle contractility, insulin secretion, cardiac function, sleep, learning, and memory.

Original languageEnglish
Title of host publicationConditional Mutagenesis
Subtitle of host publicationAn Approach to Disease Models
PublisherSpringer Science and Business Media, LLC
Pages469-490
Number of pages22
ISBN (Print)9783540351085
DOIs
StatePublished - 2007

Publication series

NameHandbook of Experimental Pharmacology
Volume178
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Blood pressure regulation
  • Insulin secretion
  • Learning and memory
  • Sparks

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