TY - CHAP
T1 - Analysis of calcium channels by conditional mutagenesis
AU - Moosmang, S.
AU - Kleppisch, T.
AU - Wegener, J.
AU - Welling, A.
AU - Hofmann, F.
PY - 2007
Y1 - 2007
N2 - Ca2+ influx through various ion channels is an important determinant of the cytosolic Ca2+ concentration, which plays a pivotal role in countless cellular processes. The cardiac L-type Ca2+ channel, Cav1.2, represents a major pathway for Ca2+ entry and is in many cells expressed together with other high- and low-voltage-activated Ca2+ channels. This article will focus on the use of conditional transgenic mouse models to clarify the roles of Ca 2+ channels in several biological systems. The phenotypes of conditional Ca2+ channel transgenic mice have provided novel, and often unexpected, insights into the in vivo function of L-type and T-type Ca2+ channels as mediators of signaling between cell membrane and intracellular processes in blood pressure regulation, smooth muscle contractility, insulin secretion, cardiac function, sleep, learning, and memory.
AB - Ca2+ influx through various ion channels is an important determinant of the cytosolic Ca2+ concentration, which plays a pivotal role in countless cellular processes. The cardiac L-type Ca2+ channel, Cav1.2, represents a major pathway for Ca2+ entry and is in many cells expressed together with other high- and low-voltage-activated Ca2+ channels. This article will focus on the use of conditional transgenic mouse models to clarify the roles of Ca 2+ channels in several biological systems. The phenotypes of conditional Ca2+ channel transgenic mice have provided novel, and often unexpected, insights into the in vivo function of L-type and T-type Ca2+ channels as mediators of signaling between cell membrane and intracellular processes in blood pressure regulation, smooth muscle contractility, insulin secretion, cardiac function, sleep, learning, and memory.
KW - Blood pressure regulation
KW - Insulin secretion
KW - Learning and memory
KW - Sparks
UR - http://www.scopus.com/inward/record.url?scp=33846939329&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-35109-2_19
DO - 10.1007/978-3-540-35109-2_19
M3 - Chapter
C2 - 17203667
AN - SCOPUS:33846939329
SN - 9783540351085
T3 - Handbook of Experimental Pharmacology
SP - 469
EP - 490
BT - Conditional Mutagenesis
PB - Springer Science and Business Media, LLC
ER -