TY - JOUR
T1 - An Investigation into the Intrinsic Peroxidase-Like Activity of Fe-MOFs and Fe-MOFs/Polymer Composites
AU - Thakur, Bhawana
AU - Karve, Vikram V.
AU - Sun, Daniel T.
AU - Semrau, A. Lisa
AU - Weiß, Lennart J.K.
AU - Grob, Leroy
AU - Fischer, Roland A.
AU - Queen, Wendy L.
AU - Wolfrum, Bernhard
N1 - Publisher Copyright:
© 2021 The Authors. Advanced Materials Technologies published by Wiley-VCH GmbH
PY - 2021/5
Y1 - 2021/5
N2 - The quest for developing materials that provide a perfect trade-off between factors such as enzyme-like response, stability, and low cost has been a long-standing challenge in the field of biosensing. Metal-organic frameworks (MOFs) and their composites have emerged as promising candidates for biosensing applications due to their exceptional properties such as tunable pore size, high specific surface area, and exposed active sites. A comparative study of the intrinsic peroxidase-like activity of five different MOF materials: Fe-BTC, NH2-MIL-101(Fe), composites of Fe-BTC with polymers polydopamine (PDA), poly p-phenylenediamine (PpPDA), and poly(3,4-ethylenedioxythiophene) is reported for the detection of H2O2, an important biomarker in biomedical diagnostics. The response of these materials toward H2O2 via electrochemical and colorimetric techniques is mapped and it is found that, at neutral pH, the Fe-BTC/PEDOT composite exhibits the highest sensitivity and activity compared to other MOF materials in this study. The results indicate that the combination of unique properties of Fe-BTC and conducting polymer PEDOT, improves the peroxidase-like activity of the Fe-BTC/PEDOT composite compared to the individual components. This work presents a new opportunity for easy-to synthesize and low-cost MOFs/conducting polymer composites for biosensing applications and provides significant insights to achieve rational design of composites with desirable functional properties.
AB - The quest for developing materials that provide a perfect trade-off between factors such as enzyme-like response, stability, and low cost has been a long-standing challenge in the field of biosensing. Metal-organic frameworks (MOFs) and their composites have emerged as promising candidates for biosensing applications due to their exceptional properties such as tunable pore size, high specific surface area, and exposed active sites. A comparative study of the intrinsic peroxidase-like activity of five different MOF materials: Fe-BTC, NH2-MIL-101(Fe), composites of Fe-BTC with polymers polydopamine (PDA), poly p-phenylenediamine (PpPDA), and poly(3,4-ethylenedioxythiophene) is reported for the detection of H2O2, an important biomarker in biomedical diagnostics. The response of these materials toward H2O2 via electrochemical and colorimetric techniques is mapped and it is found that, at neutral pH, the Fe-BTC/PEDOT composite exhibits the highest sensitivity and activity compared to other MOF materials in this study. The results indicate that the combination of unique properties of Fe-BTC and conducting polymer PEDOT, improves the peroxidase-like activity of the Fe-BTC/PEDOT composite compared to the individual components. This work presents a new opportunity for easy-to synthesize and low-cost MOFs/conducting polymer composites for biosensing applications and provides significant insights to achieve rational design of composites with desirable functional properties.
KW - H O sensors
KW - conducting polymers
KW - metal organic frameworks
KW - peroxidase-like activity
KW - polymer composites of metal organic frameworks
UR - http://www.scopus.com/inward/record.url?scp=85103020391&partnerID=8YFLogxK
U2 - 10.1002/admt.202001048
DO - 10.1002/admt.202001048
M3 - Article
AN - SCOPUS:85103020391
SN - 2365-709X
VL - 6
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
IS - 5
M1 - 2001048
ER -