An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Onur Bas; Davide D'Angella; Jeremy G. Baldwin; Nathan J. Castro; Felix M. Wunner; Navid T. Saidy; Stefan Kollmannsberger; Alessandro Reali; Ernst Rank; Elena M. De-Juan-Pardo; Dietmar W. Hutmacher

doi:10.1021/acsami.7b08617

An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Onur Bas, Davide D'Angella, Jeremy G. Baldwin, Nathan J. Castro, Felix M. Wunner, Navid T. Saidy, Stefan Kollmannsberger, Alessandro Reali, Ernst Rank, Elena M. De-Juan-Pardo, Dietmar W. Hutmacher

Engineering and Design

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (W_Ext = ∼2000 kJ m^-3) than its hydrogel counterpart.

Original language	English
Pages (from-to)	29430-29437
Number of pages	8
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	35
DOIs	https://doi.org/10.1021/acsami.7b08617
State	Published - 6 Sep 2017

Keywords

3D printing
biomimetic
fiber reinforcement
hydrogel
interpenetrating polymer network
melt electrospinning writing
soft network composite
tissue engineering

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10.1021/acsami.7b08617

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Bas, O., D'Angella, D., Baldwin, J. G., Castro, N. J., Wunner, F. M., Saidy, N. T., Kollmannsberger, S., Reali, A., Rank, E., De-Juan-Pardo, E. M., & Hutmacher, D. W. (2017). An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues. ACS Applied Materials and Interfaces, 9(35), 29430-29437. https://doi.org/10.1021/acsami.7b08617

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title = "An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues",

abstract = "We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.",

keywords = "3D printing, biomimetic, fiber reinforcement, hydrogel, interpenetrating polymer network, melt electrospinning writing, soft network composite, tissue engineering",

author = "Onur Bas and Davide D'Angella and Baldwin, {Jeremy G.} and Castro, {Nathan J.} and Wunner, {Felix M.} and Saidy, {Navid T.} and Stefan Kollmannsberger and Alessandro Reali and Ernst Rank and De-Juan-Pardo, {Elena M.} and Hutmacher, {Dietmar W.}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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doi = "10.1021/acsami.7b08617",

language = "English",

volume = "9",

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Bas, O, D'Angella, D, Baldwin, JG, Castro, NJ, Wunner, FM, Saidy, NT, Kollmannsberger, S, Reali, A, Rank, E, De-Juan-Pardo, EM & Hutmacher, DW 2017, 'An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues', ACS Applied Materials and Interfaces, vol. 9, no. 35, pp. 29430-29437. https://doi.org/10.1021/acsami.7b08617

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T1 - An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

AU - Bas, Onur

AU - D'Angella, Davide

AU - Baldwin, Jeremy G.

AU - Castro, Nathan J.

AU - Wunner, Felix M.

AU - Saidy, Navid T.

AU - Kollmannsberger, Stefan

AU - Reali, Alessandro

AU - Rank, Ernst

AU - De-Juan-Pardo, Elena M.

AU - Hutmacher, Dietmar W.

PY - 2017/9/6

Y1 - 2017/9/6

N2 - We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.

AB - We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (WExt = ∼2000 kJ m-3) than its hydrogel counterpart.

KW - 3D printing

KW - biomimetic

KW - fiber reinforcement

KW - hydrogel

KW - interpenetrating polymer network

KW - melt electrospinning writing

KW - soft network composite

KW - tissue engineering

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U2 - 10.1021/acsami.7b08617

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M3 - Article

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AN - SCOPUS:85028937233

SN - 1944-8244

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EP - 29437

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 35

ER -

An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

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