An Integrated Database of Small RNAs and Their Interplay With Transcriptional Gene Regulatory Networks in Corynebacteria

Mariana Teixeira Dornelles Parise, Doglas Parise, Flavia Figueira Aburjaile, Anne Cybelle Pinto Gomide, Rodrigo Bentes Kato, Martin Raden, Rolf Backofen, Vasco Ariston de Carvalho Azevedo, Jan Baumbach

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Small RNAs (sRNAs) are one of the key players in the post-transcriptional regulation of bacterial gene expression. These molecules, together with transcription factors, form regulatory networks and greatly influence the bacterial regulatory landscape. Little is known concerning sRNAs and their influence on the regulatory machinery in the genus Corynebacterium, despite its medical, veterinary and biotechnological importance. Here, we expand corynebacterial regulatory knowledge by integrating sRNAs and their regulatory interactions into the transcriptional regulatory networks of six corynebacterial species, covering four human and animal pathogens, and integrate this data into the CoryneRegNet database. To this end, we predicted sRNAs to regulate 754 genes, including 206 transcription factors, in corynebacterial gene regulatory networks. Amongst them, the sRNA Cd-NCTC13129-sRNA-2 is predicted to directly regulate ydfH, which indirectly regulates 66 genes, including the global regulator glxR in C. diphtheriae. All of the sRNA-enriched regulatory networks of the genus Corynebacterium have been made publicly available in the newest release of CoryneRegNet( to aid in providing valuable insights and to guide future experiments.

Original languageEnglish
Article number656435
JournalFrontiers in Microbiology
StatePublished - 17 Jun 2021


  • CoryneRegNet
  • Corynebacterium
  • gene regulatory networks
  • sRNA targets
  • small RNAs


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