An efficient and practical sequential one-pot synthesis of suprofen, ketoprofen and other 2-arylpropionic acids

Helfried Neumann, Anne Brennführer, Matthias Beller

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxycarbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium® A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.

Original languageEnglish
Pages (from-to)2437-2442
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume350
Issue number14-15
DOIs
StatePublished - 6 Oct 2008
Externally publishedYes

Keywords

  • Homogeneous catalysis
  • Hydroxycarbonylation
  • Palladium
  • Profenes
  • Suzuki carbonylation

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