Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

Maksim D. Mokrousov; Marina V. Novoselova; Jackie Nolan; Walter Harrington; Polina Rudakovskaya; Daniil N. Bratashov; Ekaterina I. Galanzha; Juan Pablo Fuenzalida-Werner; Boris P. Yakimov; Gleb Nazarikov; Vladimir P. Drachev; Evgeny A. Shirshin; Vasilis Ntziachristos; Andre C. Stiel; Vladimir P. Zharov; Dmitry A. Gorin

doi:10.1364/BOE.10.004775

Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

Maksim D. Mokrousov, Marina V. Novoselova, Jackie Nolan, Walter Harrington, Polina Rudakovskaya, Daniil N. Bratashov, Ekaterina I. Galanzha, Juan Pablo Fuenzalida-Werner, Boris P. Yakimov, Gleb Nazarikov, Vladimir P. Drachev, Evgeny A. Shirshin, Vasilis Ntziachristos, Andre C. Stiel, Vladimir P. Zharov, Dmitry A. Gorin

Chair of Biological Imaging

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.

Original language	English
Pages (from-to)	4775-4789
Number of pages	15
Journal	Biomedical Optics Express
Volume	10
Issue number	9
DOIs	https://doi.org/10.1364/BOE.10.004775
State	Published - 1 Sep 2019

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Mokrousov, M. D., Novoselova, M. V., Nolan, J., Harrington, W., Rudakovskaya, P., Bratashov, D. N., Galanzha, E. I., Fuenzalida-Werner, J. P., Yakimov, B. P., Nazarikov, G., Drachev, V. P., Shirshin, E. A., Ntziachristos, V., Stiel, A. C., Zharov, V. P., & Gorin, D. A. (2019). Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green. Biomedical Optics Express, 10(9), 4775-4789. https://doi.org/10.1364/BOE.10.004775

@article{721df327a88a4b1f905c62c4c4b9f393,

title = "Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green",

abstract = "A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.",

author = "Mokrousov, {Maksim D.} and Novoselova, {Marina V.} and Jackie Nolan and Walter Harrington and Polina Rudakovskaya and Bratashov, {Daniil N.} and Galanzha, {Ekaterina I.} and Fuenzalida-Werner, {Juan Pablo} and Yakimov, {Boris P.} and Gleb Nazarikov and Drachev, {Vladimir P.} and Shirshin, {Evgeny A.} and Vasilis Ntziachristos and Stiel, {Andre C.} and Zharov, {Vladimir P.} and Gorin, {Dmitry A.}",

note = "Publisher Copyright: {\textcopyright} 2019 Optical Society of America.",

year = "2019",

month = sep,

day = "1",

doi = "10.1364/BOE.10.004775",

language = "English",

volume = "10",

pages = "4775--4789",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "Optica Publishing Group",

number = "9",

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Mokrousov, MD, Novoselova, MV, Nolan, J, Harrington, W, Rudakovskaya, P, Bratashov, DN, Galanzha, EI, Fuenzalida-Werner, JP, Yakimov, BP, Nazarikov, G, Drachev, VP, Shirshin, EA, Ntziachristos, V, Stiel, AC, Zharov, VP & Gorin, DA 2019, 'Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green', Biomedical Optics Express, vol. 10, no. 9, pp. 4775-4789. https://doi.org/10.1364/BOE.10.004775

TY - JOUR

T1 - Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

AU - Mokrousov, Maksim D.

AU - Novoselova, Marina V.

AU - Nolan, Jackie

AU - Harrington, Walter

AU - Rudakovskaya, Polina

AU - Bratashov, Daniil N.

AU - Galanzha, Ekaterina I.

AU - Fuenzalida-Werner, Juan Pablo

AU - Yakimov, Boris P.

AU - Nazarikov, Gleb

AU - Drachev, Vladimir P.

AU - Shirshin, Evgeny A.

AU - Ntziachristos, Vasilis

AU - Stiel, Andre C.

AU - Zharov, Vladimir P.

AU - Gorin, Dmitry A.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.

AB - A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety.

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M3 - Article

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EP - 4789

JO - Biomedical Optics Express

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ER -

Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

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