Abstract
Bacterial pathogens have evolved with enzyme activities that may hijack intracellular signaling of mammalian cells to establish an infection. Of particular interest is a novel posttranslational modification referred to as adenylylation: An adenosine monophosphate group is covalently transferred to a mammalian target protein. Here, I discuss the consequences of adenylylation and its related modifications by Fic enzymes. Also, I comment on potential applications for protein labeling.
Translated title of the contribution | AMP modifications as strategies of bacterial pathogens |
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Original language | English |
Pages (from-to) | 359-361 |
Number of pages | 3 |
Journal | BioSpektrum |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Jun 2016 |