TY - JOUR
T1 - Amniotic membrane in oral and maxillofacial surgery
AU - Kesting, Marco Rainer
AU - Wolff, Klaus Dietrich
AU - Nobis, Christopher Philipp
AU - Rohleder, Nils Hagen
N1 - Funding Information:
This widespread method was supported by a multinational project initiated by the International Atomic Energy Agency. A quality management system with guidelines for retrieving, processing and distributing donor tissue was established. Gajiwala et al. described this technique extensively. AM was pasteurised at 60 °C after being cleansed, treated with 70 % ethanol and finally freeze-dried to remove 95 % of the moisture. Finally, the packed and sealed AM was sterilised by exposure to 25 kGy gamma radiation in a cobalt 60 gamma chamber unit or at an ISO-certified radiation plant []. The freeze-dried and gamma-sterilised tissue was stored at room temperature and protected from light for up to 6 months. Gomes et al. modified this conservation method by sterilisation of the AM with ethylene oxide instead of gamma radiation []. A novel technique was recently presented involving initial hyper-drying instead of freeze drying. After being washed, the amnion was dried under consecutive far-infrared rays and microwaves at temperatures lower than 60 °C by using a hyper-drying device. Final sterilisation was performed as described above with 25 kGy gamma radiation [].
PY - 2014/6
Y1 - 2014/6
N2 - Purpose: Following its renaissance in ophthalmology during the 1990s, preserved human amniotic membrane (HAM) has become an attractive biomaterial for all surgical disciplines. This article reviews the current and potential use of HAM in oral and maxillofacial surgery, its postulated properties and common preservation techniques. Methods: Literature was identified by an electronic search of PubMed in July 2012; this was supplemented from the reference lists of the consulted papers. Results: HAM has been used in the field of oral and maxillofacial surgery from 1969 onwards because of its immunological preference and its pain-reducing, antimicrobial, mechanical and side-dependent adhesive or anti-adhesive properties. The effects of HAM on dermal and mucosal re-epithelialisation have been highlighted. Typically, HAM is applied after being banked in a glycerol-preserved, DMSO-preserved or freeze-dried and irradiated state. Whereas the use of HAM in flap surgery and in intra-oral and extra-oral lining is reported frequently, novel HAM applications in post-traumatic orbital surgery and temporomandibular joint surgery have been added since 2010. Tissue engineering with HAM is a fast-expanding field with a high variety of future options. Conclusions: Preserved HAM is considered to be a safe and sufficient biomaterial in all fields of oral and maxillofacial wound healing. Recently published novel indications for HAM application lack a high level of evidence and need to be studied further.
AB - Purpose: Following its renaissance in ophthalmology during the 1990s, preserved human amniotic membrane (HAM) has become an attractive biomaterial for all surgical disciplines. This article reviews the current and potential use of HAM in oral and maxillofacial surgery, its postulated properties and common preservation techniques. Methods: Literature was identified by an electronic search of PubMed in July 2012; this was supplemented from the reference lists of the consulted papers. Results: HAM has been used in the field of oral and maxillofacial surgery from 1969 onwards because of its immunological preference and its pain-reducing, antimicrobial, mechanical and side-dependent adhesive or anti-adhesive properties. The effects of HAM on dermal and mucosal re-epithelialisation have been highlighted. Typically, HAM is applied after being banked in a glycerol-preserved, DMSO-preserved or freeze-dried and irradiated state. Whereas the use of HAM in flap surgery and in intra-oral and extra-oral lining is reported frequently, novel HAM applications in post-traumatic orbital surgery and temporomandibular joint surgery have been added since 2010. Tissue engineering with HAM is a fast-expanding field with a high variety of future options. Conclusions: Preserved HAM is considered to be a safe and sufficient biomaterial in all fields of oral and maxillofacial wound healing. Recently published novel indications for HAM application lack a high level of evidence and need to be studied further.
KW - Alternative
KW - Biomaterial
KW - Human amniotic membrane
KW - Reconstruction
KW - Wounds
UR - http://www.scopus.com/inward/record.url?scp=84901234137&partnerID=8YFLogxK
U2 - 10.1007/s10006-012-0382-1
DO - 10.1007/s10006-012-0382-1
M3 - Article
C2 - 23242942
AN - SCOPUS:84901234137
SN - 1865-1550
VL - 18
SP - 153
EP - 164
JO - Oral and Maxillofacial Surgery
JF - Oral and Maxillofacial Surgery
IS - 2
ER -