Abstract
In patients with chronic renal failure, aluminium, which is included in the dialysate or released from phosphate binders, cannot be eliminated adequately. It forms a deposit in the tissues and leads to intoxication. After a 6-month therapy with aluminium-containing phosphate binders in a non-dialysed baby with chronic renal insufficiency, an osteomalacia arose with distinct subepiphyseal and metaphyseal changes attributable to disorders of mineralization. The consequence of this was a 'bone-within-bone' appearance and pathological fractures. After a change of therapy, the bone alterations receded within a few months. Simultaneously, the distinctly elevated serum level of aluminium fell. Therefore, aluminium should be avoided in non-dialysed children with chronic renal insufficiency.
| Translated title of the contribution | Aluminium intoxication in a non-dialysed infant treated with oral aluminium hydroxide |
|---|---|
| Original language | German |
| Pages (from-to) | 327-332 |
| Number of pages | 6 |
| Journal | Radiologe |
| Volume | 32 |
| Issue number | 7 |
| State | Published - 1992 |