Altered thalamic connectivity during spontaneous attacks of migraine without aura: A resting-state fMRI study

Faisal Mohammad Amin, Anders Hougaard, Stefano Magon, Till Sprenger, Frauke Wolfram, Egill Rostrup, Messoud Ashina

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Background: Functional connectivity of brain networks may be altered in migraine without aura patients. Functional magnetic resonance imaging (fMRI) studies have demonstrated changed activity in the thalamus, pons and cerebellum in migraineurs. Here, we investigated the thalamic, pontine and cerebellar network connectivity during spontaneous migraine attacks. Methods: Seventeen patients with episodic migraine without aura underwent resting-state fMRI scan during and outside of a spontaneous migraine attack. Primary endpoint was a difference in functional connectivity between the attack and the headache-free days. Functional connectivity was assessed in four different networks using seed-based analysis. The chosen seeds were in the thalamus (MNI coordinates x,y,z: right, 22,–24,0 and left, –22,–28,6), pons (right, 8,–24,–32 and left, –8,–24,–32), cerebellum crus I (right, 46,–58,–30 and left, –46,–58,–30) and cerebellum lobule VI (right, 34,–42,–36 and left, –32,–42,–36). Results: We found increased functional connectivity between the right thalamus and several contralateral brain regions (superior parietal lobule, insular cortex, primary motor cortex, supplementary motor area and orbitofrontal cortex). There was decreased functional connectivity between the right thalamus and three ipsilateral brain areas (primary somatosensory cortex and premotor cortex). We found no change in functional connectivity in the pontine or the cerebellar networks. Conclusions: The study indicates that network connectivity between thalamus and pain modulating as well as pain encoding cortical areas are affected during spontaneous migraine attacks.

Original languageEnglish
Pages (from-to)1237-1244
Number of pages8
JournalCephalalgia
Volume38
Issue number7
DOIs
StatePublished - 1 Jun 2018
Externally publishedYes

Keywords

  • Migraine thalamus
  • migraine imaging
  • migraine pathophysiology
  • migraine resting-state fMRI

Fingerprint

Dive into the research topics of 'Altered thalamic connectivity during spontaneous attacks of migraine without aura: A resting-state fMRI study'. Together they form a unique fingerprint.

Cite this