Allelic imbalances in radiation-associated acute myeloid leukemia

Sergiy V. Klymenko; Jan Smida; Michael J. Atkinson; Volodymir G. Bebeshko; Michaela Nathrath; Michael Rosemann

doi:10.3390/genes2020384

Allelic imbalances in radiation-associated acute myeloid leukemia

Sergiy V. Klymenko, Jan Smida, Michael J. Atkinson, Volodymir G. Bebeshko, Michaela Nathrath, Michael Rosemann

Department of Pediatric Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.

Original language	English
Pages (from-to)	384-393
Number of pages	10
Journal	Genes
Volume	2
Issue number	2
DOIs	https://doi.org/10.3390/genes2020384
State	Published - Jun 2011

Keywords

Acute myeloid leukemia
Chernobyl accident
Ionizing radiation
Microarray
Single nucleotide polymorphism

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10.3390/genes2020384

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title = "Allelic imbalances in radiation-associated acute myeloid leukemia",

abstract = "Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.",

keywords = "Acute myeloid leukemia, Chernobyl accident, Ionizing radiation, Microarray, Single nucleotide polymorphism",

author = "Klymenko, {Sergiy V.} and Jan Smida and Atkinson, {Michael J.} and Bebeshko, {Volodymir G.} and Michaela Nathrath and Michael Rosemann",

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doi = "10.3390/genes2020384",

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T1 - Allelic imbalances in radiation-associated acute myeloid leukemia

AU - Klymenko, Sergiy V.

AU - Smida, Jan

AU - Atkinson, Michael J.

AU - Bebeshko, Volodymir G.

AU - Nathrath, Michaela

AU - Rosemann, Michael

PY - 2011/6

Y1 - 2011/6

N2 - Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.

AB - Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.

KW - Acute myeloid leukemia

KW - Chernobyl accident

KW - Ionizing radiation

KW - Microarray

KW - Single nucleotide polymorphism

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JO - Genes

JF - Genes

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Allelic imbalances in radiation-associated acute myeloid leukemia

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Keywords

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