All mixed up: Defining roles for β-cell subtypes in mature islets

Jennifer S.E. Liu, Matthias Hebrok

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Following differentiation during fetal development, β cells further adapt to their postnatal role through functional maturation. While adult islets are thought to contain functionally mature β cells, recent analyses of transgenic rodent and human pancreata reveal a number of novel heterogeneity markers in mammalian β cells. The marked heterogeneity long after maturation raises the prospect that diverse populations harbor distinct roles aside from glucose-stimulated insulin secretion. In this review, we outline our current understanding of the β-cell maturation process, emphasize recent literature on novel heterogeneity markers, and offer perspectives on reconciling the findings from these two areas.

Original languageEnglish
Pages (from-to)228-240
Number of pages13
JournalGenes and Development
Volume31
Issue number3
DOIs
StatePublished - 1 Feb 2017
Externally publishedYes

Keywords

  • Aging
  • Maturation
  • Pancreatic islets
  • Stem cell differentiation
  • β-cell
  • β-cell heterogeneity

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