All eyes on PCS: analysis of the retinal microvasculature in patients with post-COVID syndrome—study protocol of a 1 year prospective case–control study

Timon Kuchler, Renate Hausinger, Matthias C. Braunisch, Roman Günthner, Rebecca Wicklein, Benjamin Knier, Nathalie Bleidißel, Matthias Maier, Andrea Ribero, Maciej Lech, Kristina Adorjan, Hans Stubbe, Konstantin Kotilar, Uwe Heemann, Christoph Schmaderer

Research output: Contribution to journalArticlepeer-review

Abstract

Since widespread vaccination against COVID-19, the development of effective antiviral drugs, and the decreasing number of patients with COVID-19 in intensive care, the risk from SARS-CoV-2 infection appears less threatening. However, studies show that a significant number of patients suffer from long-term sequelae, even months after SARS-CoV-2 infection. The so-called post-COVID syndrome (PCS) often presents a diagnostic and treatment challenge for physicians. This study protocol describes the “All Eyes on PCS” study, which aims to investigate the retinal microvasculature in PCS patients and COVID-19-recovered patients to provide new insights into the pathophysiology of PCS. “All Eyes on PCS” is a prospective, case–control study with the primary objective of detecting endothelial dysfunction (ED) in patients with PCS. Therefore, we intend to recruit patients with PCS, fully SARS-CoV-2-infection-recovered (CR) participants, and SARS-CoV-2-infection-naïve (CN) participants. Baseline measurements will include: (1) patient-specific characteristics, (2) biochemistry, (3) retinal vessel analysis (RVA), (4) survey questionnaires as patient-reported outcomes measurements (PROMs), (5) optical coherence tomography (OCT), OCT angiography (OCTA), and adaptive optics (AO), (6) blood pressure recordings, (7) handgrip strength test. After 6 months, baseline measurements will be repeated in the PCS cohort, and after 1 year, a telephone query will be conducted to assess residual symptoms and treatment needs. The aim of this study is to gain insight into the pathophysiology of PCS and to provide an objective biomarker for diagnosis and treatment, while also creating a comprehensive clinical database of PCS patients. ClinicalTrials.gov Identifier: NCT05635552; Date: 2.12.2022.

Original languageEnglish
Pages (from-to)1847-1856
Number of pages10
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume274
Issue number8
DOIs
StatePublished - Dec 2024

Keywords

  • COVID-19
  • Endothelial dysfunction
  • Long-COVID
  • Post-COVID syndrome
  • Retinal microvasculature
  • SARS-CoV-2

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