AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Anapatricia García, Nagadenahalli B. Siddappa, Qingsheng Li, Ashley T. Haase, Katherine Paul, Fawn Stroud, Xiaodong Zhang, Jack A. Fountain, François Villinger, Francis J. Novembre, James G. Else, W. Evan Secor, Ruth M. Ruprecht

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalJournal of Medical Primatology
Issue number5
StatePublished - Oct 2010
Externally publishedYes


  • NeuroAIDS
  • Optic neuropathy
  • R5 SHIV


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