@article{a1540c7d5d1b4c228d38f71d0c42b670,
title = "Agouti-related peptide-expressing neurons are mandatory for feeding",
abstract = "Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.",
author = "Eva Gropp and Marya Shanabrough and Erzsebet Borok and Xu, {Allison W.} and Ruth Janoschek and Thorsten Buch and Leona Plum and Nina Balthasar and Brigitte Hampel and Ari Waisman and Barsh, {Gregory S.} and Horvath, {Tamas L.} and Br{\"u}ning, {Jens C.}",
note = "Funding Information: We wish to thank S. Irlenbusch for expert technical support and G. Schmall for excellent secretarial assistance. We wish to thank F. Schwenk and J. Seibler (Artemis Pharmaceuticals) for providing Rosa26-b-Gal-mice. This work was supported by grants from the Zentrum f{\"u}r Molekulare Medizin der Universit{\"a}t zu K{\"o}ln (TV-2) and the European Union (LSHM-CT-2003-503041) to J.C.B., from the K{\"o}ln Fortune Program (to L.P.), from the US National Institutes of Health (DK-07386 and DK-060711 to T.L.H. and DK68384 to G.S.B), and from the Deutsche Forschungsgemeinschaft (BU1410/1-1 to T.B.).",
year = "2005",
month = oct,
doi = "10.1038/nn1548",
language = "English",
volume = "8",
pages = "1289--1291",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Research",
number = "10",
}