Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

Laura de Boni; Amber Wallis; Aurelia Hays Watson; Alejandro Ruiz-Riquelme; Louise Ann Leyland; Thomas Bourinaris; Naomi Hannaway; Ullrich Wüllner; Oliver Peters; Josef Priller; Björn H. Falkenburger; Jens Wiltfang; Mathias Bähr; Inga Zerr; Katharina Bürger; Robert Perneczky; Stefan Teipel; Matthias Löhle; Wiebke Hermann; Björn Hendrik Schott; Kathrin Brockmann; Annika Spottke; Katrin Haustein; Peter Breuer; Henry Houlden; Rimona S. Weil; Tim Bartels

doi:10.1038/s44321-024-00083-5

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

Laura de Boni
, Amber Wallis
, Aurelia Hays Watson
, Alejandro Ruiz-Riquelme
, Louise Ann Leyland
, Thomas Bourinaris
, Naomi Hannaway
, Ullrich Wüllner
, Oliver Peters
, Josef Priller
, Björn H. Falkenburger
, Jens Wiltfang
, Mathias Bähr
, Inga Zerr
, Katharina Bürger
, Robert Perneczky
, Stefan Teipel
, Matthias Löhle
, Wiebke Hermann
, Björn Hendrik Schott

Kathrin Brockmann, Annika Spottke, Katrin Haustein, Peter Breuer, Henry Houlden, Rimona S. Weil, Tim Bartels

Department of Psychiatry and Psychotherapy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

Original language	English
Pages (from-to)	1657-1674
Number of pages	18
Journal	EMBO Molecular Medicine
Volume	16
Issue number	7
DOIs	https://doi.org/10.1038/s44321-024-00083-5
State	Published - 15 Jul 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alpha-synuclein
Blood
Human
Parkinson’s disease
Tetramer

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10.1038/s44321-024-00083-5

Cite this

de Boni, L., Wallis, A., Hays Watson, A., Ruiz-Riquelme, A., Leyland, L. A., Bourinaris, T., Hannaway, N., Wüllner, U., Peters, O., Priller, J., Falkenburger, B. H., Wiltfang, J., Bähr, M., Zerr, I., Bürger, K., Perneczky, R., Teipel, S., Löhle, M., Hermann, W., ... Bartels, T. (2024). Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients. EMBO Molecular Medicine, 16(7), 1657-1674. https://doi.org/10.1038/s44321-024-00083-5

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title = "Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson{\textquoteright}s patients",

abstract = "The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson{\textquoteright}s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)",

keywords = "Alpha-synuclein, Blood, Human, Parkinson{\textquoteright}s disease, Tetramer",

author = "\{de Boni\}, Laura and Amber Wallis and \{Hays Watson\}, Aurelia and Alejandro Ruiz-Riquelme and Leyland, \{Louise Ann\} and Thomas Bourinaris and Naomi Hannaway and Ullrich W{\"u}llner and Oliver Peters and Josef Priller and Falkenburger, \{Bj{\"o}rn H.\} and Jens Wiltfang and Mathias B{\"a}hr and Inga Zerr and Katharina B{\"u}rger and Robert Perneczky and Stefan Teipel and Matthias L{\"o}hle and Wiebke Hermann and Schott, \{Bj{\"o}rn Hendrik\} and Kathrin Brockmann and Annika Spottke and Katrin Haustein and Peter Breuer and Henry Houlden and Weil, \{Rimona S.\} and Tim Bartels",

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doi = "10.1038/s44321-024-00083-5",

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de Boni, L, Wallis, A, Hays Watson, A, Ruiz-Riquelme, A, Leyland, LA, Bourinaris, T, Hannaway, N, Wüllner, U, Peters, O, Priller, J, Falkenburger, BH, Wiltfang, J, Bähr, M, Zerr, I, Bürger, K, Perneczky, R, Teipel, S, Löhle, M, Hermann, W, Schott, BH, Brockmann, K, Spottke, A, Haustein, K, Breuer, P, Houlden, H, Weil, RS & Bartels, T 2024, 'Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients', EMBO Molecular Medicine, vol. 16, no. 7, pp. 1657-1674. https://doi.org/10.1038/s44321-024-00083-5

TY - JOUR

T1 - Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

AU - de Boni, Laura

AU - Wallis, Amber

AU - Hays Watson, Aurelia

AU - Ruiz-Riquelme, Alejandro

AU - Leyland, Louise Ann

AU - Bourinaris, Thomas

AU - Hannaway, Naomi

AU - Wüllner, Ullrich

AU - Peters, Oliver

AU - Priller, Josef

AU - Falkenburger, Björn H.

AU - Wiltfang, Jens

AU - Bähr, Mathias

AU - Zerr, Inga

AU - Bürger, Katharina

AU - Perneczky, Robert

AU - Teipel, Stefan

AU - Löhle, Matthias

AU - Hermann, Wiebke

AU - Schott, Björn Hendrik

AU - Brockmann, Kathrin

AU - Spottke, Annika

AU - Haustein, Katrin

AU - Breuer, Peter

AU - Houlden, Henry

AU - Weil, Rimona S.

AU - Bartels, Tim

PY - 2024/7/15

Y1 - 2024/7/15

N2 - The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

AB - The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

KW - Alpha-synuclein

KW - Blood

KW - Human

KW - Parkinson’s disease

KW - Tetramer

UR - https://www.scopus.com/pages/publications/85195313330

U2 - 10.1038/s44321-024-00083-5

DO - 10.1038/s44321-024-00083-5

M3 - Article

AN - SCOPUS:85195313330

SN - 1757-4676

VL - 16

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EP - 1674

JO - EMBO Molecular Medicine

JF - EMBO Molecular Medicine

IS - 7

ER -

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

Abstract

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Keywords

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