Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

Laura de Boni; Amber Wallis; Aurelia Hays Watson; Alejandro Ruiz-Riquelme; Louise Ann Leyland; Thomas Bourinaris; Naomi Hannaway; Ullrich Wüllner; Oliver Peters; Josef Priller; Björn H. Falkenburger; Jens Wiltfang; Mathias Bähr; Inga Zerr; Katharina Bürger; Robert Perneczky; Stefan Teipel; Matthias Löhle; Wiebke Hermann; Björn Hendrik Schott; Kathrin Brockmann; Annika Spottke; Katrin Haustein; Peter Breuer; Henry Houlden; Rimona S. Weil; Tim Bartels

doi:10.1038/s44321-024-00083-5

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

Laura de Boni, Amber Wallis, Aurelia Hays Watson, Alejandro Ruiz-Riquelme, Louise Ann Leyland, Thomas Bourinaris, Naomi Hannaway, Ullrich Wüllner, Oliver Peters, Josef Priller, Björn H. Falkenburger, Jens Wiltfang, Mathias Bähr, Inga Zerr, Katharina Bürger, Robert Perneczky, Stefan Teipel, Matthias Löhle, Wiebke Hermann, Björn Hendrik SchottKathrin Brockmann, Annika Spottke, Katrin Haustein, Peter Breuer, Henry Houlden, Rimona S. Weil, Tim Bartels

Department of Psychiatry and Psychotherapy

Research output: Contribution to journal › Article › peer-review

Abstract

The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

Original language	English
Pages (from-to)	1657-1674
Number of pages	18
Journal	EMBO Molecular Medicine
Volume	16
Issue number	7
DOIs	https://doi.org/10.1038/s44321-024-00083-5
State	Published - 15 Jul 2024

Keywords

Alpha-synuclein
Blood
Human
Parkinson’s disease
Tetramer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s44321-024-00083-5

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de Boni, L., Wallis, A., Hays Watson, A., Ruiz-Riquelme, A., Leyland, L. A., Bourinaris, T., Hannaway, N., Wüllner, U., Peters, O., Priller, J., Falkenburger, B. H., Wiltfang, J., Bähr, M., Zerr, I., Bürger, K., Perneczky, R., Teipel, S., Löhle, M., Hermann, W., ... Bartels, T. (2024). Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients. EMBO Molecular Medicine, 16(7), 1657-1674. https://doi.org/10.1038/s44321-024-00083-5

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title = "Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson{\textquoteright}s patients",

abstract = "The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson{\textquoteright}s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)",

keywords = "Alpha-synuclein, Blood, Human, Parkinson{\textquoteright}s disease, Tetramer",

author = "{de Boni}, Laura and Amber Wallis and {Hays Watson}, Aurelia and Alejandro Ruiz-Riquelme and Leyland, {Louise Ann} and Thomas Bourinaris and Naomi Hannaway and Ullrich W{\"u}llner and Oliver Peters and Josef Priller and Falkenburger, {Bj{\"o}rn H.} and Jens Wiltfang and Mathias B{\"a}hr and Inga Zerr and Katharina B{\"u}rger and Robert Perneczky and Stefan Teipel and Matthias L{\"o}hle and Wiebke Hermann and Schott, {Bj{\"o}rn Hendrik} and Kathrin Brockmann and Annika Spottke and Katrin Haustein and Peter Breuer and Henry Houlden and Weil, {Rimona S.} and Tim Bartels",

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doi = "10.1038/s44321-024-00083-5",

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de Boni, L, Wallis, A, Hays Watson, A, Ruiz-Riquelme, A, Leyland, LA, Bourinaris, T, Hannaway, N, Wüllner, U, Peters, O, Priller, J, Falkenburger, BH, Wiltfang, J, Bähr, M, Zerr, I, Bürger, K, Perneczky, R, Teipel, S, Löhle, M, Hermann, W, Schott, BH, Brockmann, K, Spottke, A, Haustein, K, Breuer, P, Houlden, H, Weil, RS & Bartels, T 2024, 'Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients', EMBO Molecular Medicine, vol. 16, no. 7, pp. 1657-1674. https://doi.org/10.1038/s44321-024-00083-5

TY - JOUR

T1 - Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

AU - de Boni, Laura

AU - Wallis, Amber

AU - Hays Watson, Aurelia

AU - Ruiz-Riquelme, Alejandro

AU - Leyland, Louise Ann

AU - Bourinaris, Thomas

AU - Hannaway, Naomi

AU - Wüllner, Ullrich

AU - Peters, Oliver

AU - Priller, Josef

AU - Falkenburger, Björn H.

AU - Wiltfang, Jens

AU - Bähr, Mathias

AU - Zerr, Inga

AU - Bürger, Katharina

AU - Perneczky, Robert

AU - Teipel, Stefan

AU - Löhle, Matthias

AU - Hermann, Wiebke

AU - Schott, Björn Hendrik

AU - Brockmann, Kathrin

AU - Spottke, Annika

AU - Haustein, Katrin

AU - Breuer, Peter

AU - Houlden, Henry

AU - Weil, Rimona S.

AU - Bartels, Tim

PY - 2024/7/15

Y1 - 2024/7/15

N2 - The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

AB - The α-synuclein protein exists in different structural forms primarily as monomers, dimers, and tetramers in different human tissues. In the brain and blood, α-synuclein tetramer to monomer ratios are observed to be altered in sporadic and familial Parkinson’s disease (sPD), and dementia with Lewy bodies (DLB). (Figure presented.)

KW - Alpha-synuclein

KW - Blood

KW - Human

KW - Parkinson’s disease

KW - Tetramer

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DO - 10.1038/s44321-024-00083-5

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VL - 16

SP - 1657

EP - 1674

JO - EMBO Molecular Medicine

JF - EMBO Molecular Medicine

IS - 7

ER -

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

Abstract

Keywords

UN SDGs

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