TY - JOUR
T1 - Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling
AU - Preibisch, Christine
AU - Sorg, Christian
AU - Förschler, Annette
AU - Grimmer, Timo
AU - Sax, Iris
AU - Wohlschläger, Afra M.
AU - Perneczky, Robert
AU - Förstl, Hans
AU - Kurz, Alexander
AU - Zimmer, Claus
AU - Alexopoulos, Panagiotis
PY - 2011/12
Y1 - 2011/12
N2 - Purpose: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods: Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique. Results: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique. Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.
AB - Purpose: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods: Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique. Results: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique. Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.
KW - ageing
KW - cerebral blood flow (CBF)
KW - human brain
KW - magnetic resonance imaging (MRI)
KW - perfusion
KW - pulsed arterial spin labeling (PASL)
KW - reproducibility
UR - http://www.scopus.com/inward/record.url?scp=81755163087&partnerID=8YFLogxK
U2 - 10.1002/jmri.22788
DO - 10.1002/jmri.22788
M3 - Article
C2 - 21953683
AN - SCOPUS:81755163087
SN - 1053-1807
VL - 34
SP - 1295
EP - 1302
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 6
ER -