Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling

Christine Preibisch, Christian Sorg, Annette Förschler, Timo Grimmer, Iris Sax, Afra M. Wohlschläger, Robert Perneczky, Hans Förstl, Alexander Kurz, Claus Zimmer, Panagiotis Alexopoulos

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Purpose: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. Materials and Methods: Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique. Results: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique. Conclusion: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.

Original languageEnglish
Pages (from-to)1295-1302
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume34
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • ageing
  • cerebral blood flow (CBF)
  • human brain
  • magnetic resonance imaging (MRI)
  • perfusion
  • pulsed arterial spin labeling (PASL)
  • reproducibility

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