Age-dependent increase of cytoskeletal components in sensory axons in human skin

Klara Metzner; Omar Darawsha; Mengzhe Wang; Nayana Gaur; Yiming Cheng; Annekathrin Rödiger; Christiane Frahm; Otto W. Witte; Fabiana Perocchi; Hubertus Axer; Julian Grosskreutz; Monika S. Brill

doi:10.3389/fcell.2022.965382

Age-dependent increase of cytoskeletal components in sensory axons in human skin

Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Monika S. Brill

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals, we investigate alterations in cytoskeletal content and sensory axon caliber during aging via quantitative immunostainings. Cytoskeletal components show an increase with aging in both sexes, while elevation in axon diameter is only evident in males. Transcriptomic data from aging males illustrate various patterns in gene expression during aging. Together, the data suggest gender-specific changes during aging in peripheral sensory axons, possibly influencing cytoskeletal functionality and axonal caliber. These changes may cumulatively increase susceptibility of aged individuals to neurodegenerative diseases.

Original language	English
Article number	965382
Journal	Frontiers in Cell and Developmental Biology
Volume	10
DOIs	https://doi.org/10.3389/fcell.2022.965382
State	Published - 1 Nov 2022
Externally published	Yes

Keywords

actin
aging adults
human skin biopsy
microtubule
neurofilament
sensory axon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcell.2022.965382

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@article{abda57693ed94225a5397d20635b2790,

title = "Age-dependent increase of cytoskeletal components in sensory axons in human skin",

abstract = "Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals, we investigate alterations in cytoskeletal content and sensory axon caliber during aging via quantitative immunostainings. Cytoskeletal components show an increase with aging in both sexes, while elevation in axon diameter is only evident in males. Transcriptomic data from aging males illustrate various patterns in gene expression during aging. Together, the data suggest gender-specific changes during aging in peripheral sensory axons, possibly influencing cytoskeletal functionality and axonal caliber. These changes may cumulatively increase susceptibility of aged individuals to neurodegenerative diseases.",

keywords = "actin, aging adults, human skin biopsy, microtubule, neurofilament, sensory axon",

author = "Klara Metzner and Omar Darawsha and Mengzhe Wang and Nayana Gaur and Yiming Cheng and Annekathrin R{\"o}diger and Christiane Frahm and Witte, {Otto W.} and Fabiana Perocchi and Hubertus Axer and Julian Grosskreutz and Brill, {Monika S.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Metzner, Darawsha, Wang, Gaur, Cheng, R{\"o}diger, Frahm, Witte, Perocchi, Axer, Grosskreutz and Brill.",

year = "2022",

month = nov,

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doi = "10.3389/fcell.2022.965382",

language = "English",

volume = "10",

journal = "Frontiers in Cell and Developmental Biology",

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TY - JOUR

T1 - Age-dependent increase of cytoskeletal components in sensory axons in human skin

AU - Metzner, Klara

AU - Darawsha, Omar

AU - Wang, Mengzhe

AU - Gaur, Nayana

AU - Cheng, Yiming

AU - Rödiger, Annekathrin

AU - Frahm, Christiane

AU - Witte, Otto W.

AU - Perocchi, Fabiana

AU - Axer, Hubertus

AU - Grosskreutz, Julian

AU - Brill, Monika S.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals, we investigate alterations in cytoskeletal content and sensory axon caliber during aging via quantitative immunostainings. Cytoskeletal components show an increase with aging in both sexes, while elevation in axon diameter is only evident in males. Transcriptomic data from aging males illustrate various patterns in gene expression during aging. Together, the data suggest gender-specific changes during aging in peripheral sensory axons, possibly influencing cytoskeletal functionality and axonal caliber. These changes may cumulatively increase susceptibility of aged individuals to neurodegenerative diseases.

AB - Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals, we investigate alterations in cytoskeletal content and sensory axon caliber during aging via quantitative immunostainings. Cytoskeletal components show an increase with aging in both sexes, while elevation in axon diameter is only evident in males. Transcriptomic data from aging males illustrate various patterns in gene expression during aging. Together, the data suggest gender-specific changes during aging in peripheral sensory axons, possibly influencing cytoskeletal functionality and axonal caliber. These changes may cumulatively increase susceptibility of aged individuals to neurodegenerative diseases.

KW - actin

KW - aging adults

KW - human skin biopsy

KW - microtubule

KW - neurofilament

KW - sensory axon

UR - http://www.scopus.com/inward/record.url?scp=85142040795&partnerID=8YFLogxK

U2 - 10.3389/fcell.2022.965382

DO - 10.3389/fcell.2022.965382

M3 - Article

AN - SCOPUS:85142040795

SN - 2296-634X

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 965382

ER -

Age-dependent increase of cytoskeletal components in sensory axons in human skin

Abstract

Keywords

UN SDGs

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