Advances in the visualization of unstained brain tumors using grating-based x-ray phase-contrast tomography

Franz Pfeiffer, Oliver Bunk, Christian David, Martin Bech, Geraldine Le Duc, Alberto Bravin, Peter Cloetens

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


We report advances and complementary results concerning a recently developed method for high-sensitivity grating-based hard x-ray phase tomography. We demonstrate how the soft tissue sensitivity of the technique can be used to obtain in-vitro tomographic images of a tumor bearing rat brain specimen, without use of contrast agents. In particular, we demonstrate that brain tumors and the white and gray brain matter structure in a rat's cerebellum can be resolved by this approach. The findings are potentially interesting from a clinical point of view, since a similar approach using three transmission gratings can be implemented with more readily available x-ray sources, such as standard x-ray tubes. Moreover, open the results the way to in-vivo experiments in the near future.

Original languageEnglish
Title of host publicationDevelopments in X-Ray Tomography VI
StatePublished - 2008
Externally publishedYes
EventDevelopments in X-Ray Tomography VI - San Diego, CA, United States
Duration: 12 Aug 200814 Aug 2008

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferenceDevelopments in X-Ray Tomography VI
Country/TerritoryUnited States
CitySan Diego, CA


  • Phase contrast
  • Tumor visualization
  • X-ray computed tomography


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