Advances in magnetofection - Magnetically guided nucleic acid delivery

Ulrike Schillinger, Thomas Brill, Carsten Rudolph, Stephanie Huth, Sören Gersting, Florian Krötz, Johannes Hirschberger, Christian Bergemann, Christian Plank

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

Magnetofection is nucleic acid delivery to cells supported and site-specifically guided by the attractive forces of magnetic fields acting on nucleic acid shuttles (vectors) which are associated with magnetic nanoparticles. Recent progress with the method confirms its general applicability with small and large nucleic acids and viruses. The method's therapeutic application as well as mechanistic studies will be discussed.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalJournal of Magnetism and Magnetic Materials
Volume293
Issue number1
DOIs
StatePublished - May 2005

Keywords

  • Gene delivery
  • Gene therapy
  • Magnetic drug targeting
  • Magnetofection

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