Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment

Hao Wang; Jose A. Gomez; Sabine Klein; Zhiping Zhang; Barbara Seidler; Yanqiang Yang; Jeffrey Schmeckpeper; Lunan Zhang; Garrett G. Muramoto; John Chute; Richard E. Pratt; Dieter Saur; Maria Mirotsou; Victor J. Dzau

doi:10.1681/ASN.2012060596

Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment

Hao Wang, Jose A. Gomez, Sabine Klein, Zhiping Zhang, Barbara Seidler, Yanqiang Yang, Jeffrey Schmeckpeper, Lunan Zhang, Garrett G. Muramoto, John Chute, Richard E. Pratt, Dieter Saur, Maria Mirotsou, Victor J. Dzau

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37 Scopus citations

Abstract

The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44⁺ mesenchymal stemcell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44⁺ MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.

Original language	English
Pages (from-to)	1263-1273
Number of pages	11
Journal	Journal of the American Society of Nephrology
Volume	24
Issue number	8
DOIs	https://doi.org/10.1681/ASN.2012060596
State	Published - 31 Jul 2013
Externally published	Yes

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Wang, H., Gomez, J. A., Klein, S., Zhang, Z., Seidler, B., Yang, Y., Schmeckpeper, J., Zhang, L., Muramoto, G. G., Chute, J., Pratt, R. E., Saur, D., Mirotsou, M., & Dzau, V. J. (2013). Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment. Journal of the American Society of Nephrology, 24(8), 1263-1273. https://doi.org/10.1681/ASN.2012060596

@article{562c90039e134435980d2d9f036514c0,

title = "Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment",

abstract = "The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44+ mesenchymal stemcell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44+ MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.",

author = "Hao Wang and Gomez, {Jose A.} and Sabine Klein and Zhiping Zhang and Barbara Seidler and Yanqiang Yang and Jeffrey Schmeckpeper and Lunan Zhang and Muramoto, {Garrett G.} and John Chute and Pratt, {Richard E.} and Dieter Saur and Maria Mirotsou and Dzau, {Victor J.}",

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doi = "10.1681/ASN.2012060596",

language = "English",

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Wang, H, Gomez, JA, Klein, S, Zhang, Z, Seidler, B, Yang, Y, Schmeckpeper, J, Zhang, L, Muramoto, GG, Chute, J, Pratt, RE, Saur, D, Mirotsou, M & Dzau, VJ 2013, 'Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment', Journal of the American Society of Nephrology, vol. 24, no. 8, pp. 1263-1273. https://doi.org/10.1681/ASN.2012060596

TY - JOUR

T1 - Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment

AU - Wang, Hao

AU - Gomez, Jose A.

AU - Klein, Sabine

AU - Zhang, Zhiping

AU - Seidler, Barbara

AU - Yang, Yanqiang

AU - Schmeckpeper, Jeffrey

AU - Zhang, Lunan

AU - Muramoto, Garrett G.

AU - Chute, John

AU - Pratt, Richard E.

AU - Saur, Dieter

AU - Mirotsou, Maria

AU - Dzau, Victor J.

PY - 2013/7/31

Y1 - 2013/7/31

N2 - The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44+ mesenchymal stemcell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44+ MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.

AB - The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44+ mesenchymal stemcell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44+ MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.

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Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment

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