Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B

F. Bohne, U. Protzer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The human hepatitis B virus is a small, enveloped and non-cytopathic virus, with a very narrow host range and a strong liver tropism causing acute and chronic liver disease. Although a well-tolerated vaccine is available, more than 350 million people are chronically infected worldwide. Available therapies for chronic hepatitis B only rarely eliminate the virus. Although new antivirals are being developed, long-term treatment is required, which may be limited by the selection of resistant viruses. Therefore, immunotherapies are investigated as an approach to eliminate persistently infected cells. Besides therapeutic vaccination, adoptive T-cell therapy is an interesting option, which is discussed in this review.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Viral Hepatitis
Issue numberSUPPL. 1
StatePublished - Nov 2007


  • Adoptive T-cell transfer
  • Chimeric TCR
  • HBV
  • T-cell receptor


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