Adoptive Immunotherapy: Guidelines and Clinical Practice

Hans Jochem Kolb; Christoph Schmid; Iris Bigalke; Raymund Buhmann; Belinda Simoes; Ting Yang; Johanna Tischer; Michael Stanglmaier; Horst Lindhofer; Christine Falk; Georg Ledderose

doi:10.1002/3527608745.ch14

Adoptive Immunotherapy: Guidelines and Clinical Practice

Hans Jochem Kolb, Christoph Schmid, Iris Bigalke, Raymund Buhmann, Belinda Simoes, Ting Yang, Johanna Tischer, Michael Stanglmaier, Horst Lindhofer, Christine Falk, Georg Ledderose

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Allogeneic stem cell transplantation may induce lasting remissions in leukemia and hematological malignancies that otherwise are refractory to chemotherapy. An important role in the control of the disease is played by immune competent cells of the graft. This role has been most convincingly demonstrated by the effect of donor lymphocyte transfusions for the treatment of recurrent chronic myelogenous leukemia. In other forms of leukemia and hematological malignancies this role has been less clearly defined. In this chapter, strategies are discussed to improve the effect of donor lymphocyte transfusions. Methods to improve responses have involved the use of cytokines, natural killer cells, and antibodies.

Original language	English
Title of host publication	Stem Cell Transplantation
Subtitle of host publication	Biology, Processing, and Therapy
Publisher	Wiley-VCH Verlag GmbH & Co. KGaA
Pages	221-231
Number of pages	11
ISBN (Print)	3527310185, 9783527310180
DOIs	https://doi.org/10.1002/3527608745.ch14
State	Published - 28 Aug 2006
Externally published	Yes

Keywords

Adoptive immunotherapy
Animal experiments
Bispecific antibodies
Clinical applications
Cytokines
EBMT study
First clinical results in CML
Graft-versus-leukemia effect
HLA-haploidentical transplantation
NK and NK-T cells transplantation
Stem cell biology
Transplantation

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10.1002/3527608745.ch14

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abstract = "Allogeneic stem cell transplantation may induce lasting remissions in leukemia and hematological malignancies that otherwise are refractory to chemotherapy. An important role in the control of the disease is played by immune competent cells of the graft. This role has been most convincingly demonstrated by the effect of donor lymphocyte transfusions for the treatment of recurrent chronic myelogenous leukemia. In other forms of leukemia and hematological malignancies this role has been less clearly defined. In this chapter, strategies are discussed to improve the effect of donor lymphocyte transfusions. Methods to improve responses have involved the use of cytokines, natural killer cells, and antibodies.",

keywords = "Adoptive immunotherapy, Animal experiments, Bispecific antibodies, Clinical applications, Cytokines, EBMT study, First clinical results in CML, Graft-versus-leukemia effect, HLA-haploidentical transplantation, NK and NK-T cells transplantation, Stem cell biology, Transplantation",

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T2 - Guidelines and Clinical Practice

AU - Kolb, Hans Jochem

AU - Schmid, Christoph

AU - Bigalke, Iris

AU - Buhmann, Raymund

AU - Simoes, Belinda

AU - Yang, Ting

AU - Tischer, Johanna

AU - Stanglmaier, Michael

AU - Lindhofer, Horst

AU - Falk, Christine

AU - Ledderose, Georg

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AB - Allogeneic stem cell transplantation may induce lasting remissions in leukemia and hematological malignancies that otherwise are refractory to chemotherapy. An important role in the control of the disease is played by immune competent cells of the graft. This role has been most convincingly demonstrated by the effect of donor lymphocyte transfusions for the treatment of recurrent chronic myelogenous leukemia. In other forms of leukemia and hematological malignancies this role has been less clearly defined. In this chapter, strategies are discussed to improve the effect of donor lymphocyte transfusions. Methods to improve responses have involved the use of cytokines, natural killer cells, and antibodies.

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KW - Animal experiments

KW - Bispecific antibodies

KW - Clinical applications

KW - Cytokines

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KW - First clinical results in CML

KW - Graft-versus-leukemia effect

KW - HLA-haploidentical transplantation

KW - NK and NK-T cells transplantation

KW - Stem cell biology

KW - Transplantation

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PB - Wiley-VCH Verlag GmbH & Co. KGaA

ER -

Adoptive Immunotherapy: Guidelines and Clinical Practice

Abstract

Keywords

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