Adoptive Immunotherapy: Guidelines and Clinical Practice

Hans Jochem Kolb, Christoph Schmid, Iris Bigalke, Raymund Buhmann, Belinda Simoes, Ting Yang, Johanna Tischer, Michael Stanglmaier, Horst Lindhofer, Christine Falk, Georg Ledderose

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Allogeneic stem cell transplantation may induce lasting remissions in leukemia and hematological malignancies that otherwise are refractory to chemotherapy. An important role in the control of the disease is played by immune competent cells of the graft. This role has been most convincingly demonstrated by the effect of donor lymphocyte transfusions for the treatment of recurrent chronic myelogenous leukemia. In other forms of leukemia and hematological malignancies this role has been less clearly defined. In this chapter, strategies are discussed to improve the effect of donor lymphocyte transfusions. Methods to improve responses have involved the use of cytokines, natural killer cells, and antibodies.

Original languageEnglish
Title of host publicationStem Cell Transplantation
Subtitle of host publicationBiology, Processing, and Therapy
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Pages221-231
Number of pages11
ISBN (Print)3527310185, 9783527310180
DOIs
StatePublished - 28 Aug 2006
Externally publishedYes

Keywords

  • Adoptive immunotherapy
  • Animal experiments
  • Bispecific antibodies
  • Clinical applications
  • Cytokines
  • EBMT study
  • First clinical results in CML
  • Graft-versus-leukemia effect
  • HLA-haploidentical transplantation
  • NK and NK-T cells transplantation
  • Stem cell biology
  • Transplantation

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