Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible

James A. Hutchinson; Felix Gövert; Paloma Riquelme; Jan Hinrich Bräsen; Beate G. Brem-Exner; Martina Matthäi; Maren Schulze; Lutz Renders; Ulrich Kunzendorf; Edward K. Geissler; Fred Fändrich

doi:10.1111/j.1399-0012.2008.00953.x

Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible

James A. Hutchinson, Felix Gövert, Paloma Riquelme, Jan Hinrich Bräsen, Beate G. Brem-Exner, Martina Matthäi, Maren Schulze, Lutz Renders, Ulrich Kunzendorf, Edward K. Geissler, Fred Fändrich

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Patient KW, a 36-yr-old male renal transplant recipient, received transplant acceptance-inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post-transplantation, the patient's conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post-transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four-yr follow-up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.

Original language	English
Pages (from-to)	140-145
Number of pages	6
Journal	Clinical Transplantation
Volume	23
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0012.2008.00953.x
State	Published - 2009
Externally published	Yes

Keywords

Cell-based immunotherapy
Regulatory macrophage

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Hutchinson, J. A., Gövert, F., Riquelme, P., Bräsen, J. H., Brem-Exner, B. G., Matthäi, M., Schulze, M., Renders, L., Kunzendorf, U., Geissler, E. K., & Fändrich, F. (2009). Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible. Clinical Transplantation, 23(1), 140-145. https://doi.org/10.1111/j.1399-0012.2008.00953.x

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title = "Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible",

abstract = "Patient KW, a 36-yr-old male renal transplant recipient, received transplant acceptance-inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post-transplantation, the patient's conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post-transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four-yr follow-up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.",

keywords = "Cell-based immunotherapy, Regulatory macrophage",

author = "Hutchinson, {James A.} and Felix G{\"o}vert and Paloma Riquelme and Br{\"a}sen, {Jan Hinrich} and Brem-Exner, {Beate G.} and Martina Matth{\"a}i and Maren Schulze and Lutz Renders and Ulrich Kunzendorf and Geissler, {Edward K.} and Fred F{\"a}ndrich",

year = "2009",

doi = "10.1111/j.1399-0012.2008.00953.x",

language = "English",

volume = "23",

pages = "140--145",

journal = "Clinical Transplantation",

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Hutchinson, JA, Gövert, F, Riquelme, P, Bräsen, JH, Brem-Exner, BG, Matthäi, M, Schulze, M, Renders, L, Kunzendorf, U, Geissler, EK & Fändrich, F 2009, 'Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible', Clinical Transplantation, vol. 23, no. 1, pp. 140-145. https://doi.org/10.1111/j.1399-0012.2008.00953.x

TY - JOUR

T1 - Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible

AU - Hutchinson, James A.

AU - Gövert, Felix

AU - Riquelme, Paloma

AU - Bräsen, Jan Hinrich

AU - Brem-Exner, Beate G.

AU - Matthäi, Martina

AU - Schulze, Maren

AU - Renders, Lutz

AU - Kunzendorf, Ulrich

AU - Geissler, Edward K.

AU - Fändrich, Fred

PY - 2009

Y1 - 2009

N2 - Patient KW, a 36-yr-old male renal transplant recipient, received transplant acceptance-inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post-transplantation, the patient's conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post-transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four-yr follow-up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.

AB - Patient KW, a 36-yr-old male renal transplant recipient, received transplant acceptance-inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post-transplantation, the patient's conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post-transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four-yr follow-up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.

KW - Cell-based immunotherapy

KW - Regulatory macrophage

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DO - 10.1111/j.1399-0012.2008.00953.x

M3 - Article

C2 - 19200227

AN - SCOPUS:63349100101

SN - 0902-0063

VL - 23

SP - 140

EP - 145

JO - Clinical Transplantation

JF - Clinical Transplantation

IS - 1

ER -

Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible

Abstract

Keywords

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